Cargando…
Acute tubulointerstitial nephritis and COVID-19
Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that to date has spread to >100 countries. Acute kidney injury is not uncommon with this disease. The most common kidney biopsy finding is acute tubular injury. Glomerular diseases such as collapsing glomerulopathy and vasculitis, and thr...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344665/ https://www.ncbi.nlm.nih.gov/pubmed/34603692 http://dx.doi.org/10.1093/ckj/sfab107 |
_version_ | 1783734490927988736 |
---|---|
author | Ng, Jia H Zaidan, Mohamad Jhaveri, Kenar D Izzedine, Hassan |
author_facet | Ng, Jia H Zaidan, Mohamad Jhaveri, Kenar D Izzedine, Hassan |
author_sort | Ng, Jia H |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that to date has spread to >100 countries. Acute kidney injury is not uncommon with this disease. The most common kidney biopsy finding is acute tubular injury. Glomerular diseases such as collapsing glomerulopathy and vasculitis, and thrombotic microangiopathy have been reported. Viral inclusion particles with distinctive spikes in the tubular epithelium and podocytes, and endothelial cells of the glomerular capillary loops, have been visualized by electron microscopy by some but disputed by others as non-viral structures. Interstitial infiltrates have not commonly been described in the published kidney biopsy series from patients with COVID-19. Medications used to treat COVID-19 can lead to interstitial nephritis, but very few have been reported. In summary, interstitial kidney disease is a rare finding in COVID-19. |
format | Online Article Text |
id | pubmed-8344665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-83446652021-08-10 Acute tubulointerstitial nephritis and COVID-19 Ng, Jia H Zaidan, Mohamad Jhaveri, Kenar D Izzedine, Hassan Clin Kidney J CKJ Reviews Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that to date has spread to >100 countries. Acute kidney injury is not uncommon with this disease. The most common kidney biopsy finding is acute tubular injury. Glomerular diseases such as collapsing glomerulopathy and vasculitis, and thrombotic microangiopathy have been reported. Viral inclusion particles with distinctive spikes in the tubular epithelium and podocytes, and endothelial cells of the glomerular capillary loops, have been visualized by electron microscopy by some but disputed by others as non-viral structures. Interstitial infiltrates have not commonly been described in the published kidney biopsy series from patients with COVID-19. Medications used to treat COVID-19 can lead to interstitial nephritis, but very few have been reported. In summary, interstitial kidney disease is a rare finding in COVID-19. Oxford University Press 2021-07-11 /pmc/articles/PMC8344665/ /pubmed/34603692 http://dx.doi.org/10.1093/ckj/sfab107 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of ERA-EDTA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | CKJ Reviews Ng, Jia H Zaidan, Mohamad Jhaveri, Kenar D Izzedine, Hassan Acute tubulointerstitial nephritis and COVID-19 |
title | Acute tubulointerstitial nephritis and COVID-19 |
title_full | Acute tubulointerstitial nephritis and COVID-19 |
title_fullStr | Acute tubulointerstitial nephritis and COVID-19 |
title_full_unstemmed | Acute tubulointerstitial nephritis and COVID-19 |
title_short | Acute tubulointerstitial nephritis and COVID-19 |
title_sort | acute tubulointerstitial nephritis and covid-19 |
topic | CKJ Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344665/ https://www.ncbi.nlm.nih.gov/pubmed/34603692 http://dx.doi.org/10.1093/ckj/sfab107 |
work_keys_str_mv | AT ngjiah acutetubulointerstitialnephritisandcovid19 AT zaidanmohamad acutetubulointerstitialnephritisandcovid19 AT jhaverikenard acutetubulointerstitialnephritisandcovid19 AT izzedinehassan acutetubulointerstitialnephritisandcovid19 |