Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019

We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite selection of CCP with significantly higher total immunoglobulin G t...

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Autores principales: Bainbridge, Emma D, Hsue, Priscilla Y, Esensten, Jonathan H, Lynch, Kara L, Hendrickson, Carolyn M, Doernberg, Sarah B, Fung, Monica, Chin-Hong, Peter, Di Germanio, Clara, Norris, Philip J, Simmons, Graham, Glidden, David V, Luetkemeyer, Anne F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344822/
https://www.ncbi.nlm.nih.gov/pubmed/34405093
http://dx.doi.org/10.1093/ofid/ofab385
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author Bainbridge, Emma D
Hsue, Priscilla Y
Esensten, Jonathan H
Lynch, Kara L
Hendrickson, Carolyn M
Doernberg, Sarah B
Fung, Monica
Chin-Hong, Peter
Di Germanio, Clara
Norris, Philip J
Simmons, Graham
Glidden, David V
Luetkemeyer, Anne F
author_facet Bainbridge, Emma D
Hsue, Priscilla Y
Esensten, Jonathan H
Lynch, Kara L
Hendrickson, Carolyn M
Doernberg, Sarah B
Fung, Monica
Chin-Hong, Peter
Di Germanio, Clara
Norris, Philip J
Simmons, Graham
Glidden, David V
Luetkemeyer, Anne F
author_sort Bainbridge, Emma D
collection PubMed
description We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite selection of CCP with significantly higher total immunoglobulin G than recipients, neutralizing antibody levels did not differ between donor plasma and CCP recipients.
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spelling pubmed-83448222021-08-10 Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019 Bainbridge, Emma D Hsue, Priscilla Y Esensten, Jonathan H Lynch, Kara L Hendrickson, Carolyn M Doernberg, Sarah B Fung, Monica Chin-Hong, Peter Di Germanio, Clara Norris, Philip J Simmons, Graham Glidden, David V Luetkemeyer, Anne F Open Forum Infect Dis Brief Reports We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite selection of CCP with significantly higher total immunoglobulin G than recipients, neutralizing antibody levels did not differ between donor plasma and CCP recipients. Oxford University Press 2021-07-16 /pmc/articles/PMC8344822/ /pubmed/34405093 http://dx.doi.org/10.1093/ofid/ofab385 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Bainbridge, Emma D
Hsue, Priscilla Y
Esensten, Jonathan H
Lynch, Kara L
Hendrickson, Carolyn M
Doernberg, Sarah B
Fung, Monica
Chin-Hong, Peter
Di Germanio, Clara
Norris, Philip J
Simmons, Graham
Glidden, David V
Luetkemeyer, Anne F
Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019
title Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019
title_full Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019
title_fullStr Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019
title_full_unstemmed Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019
title_short Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019
title_sort characteristics of high-titer convalescent plasma and antibody dynamics after administration in patients with severe coronavirus disease 2019
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344822/
https://www.ncbi.nlm.nih.gov/pubmed/34405093
http://dx.doi.org/10.1093/ofid/ofab385
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