The CPNE Family and Their Role in Cancers

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite significant advances in cancer research and treatment, the overall prognosis of lung cancer patients remains poor. Therefore, the identification for novel therapeutic targets is critical for the diagnosis and treatment of l...

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Autores principales: Tang, Haicheng, Pang, Pei, Qin, Zhu, Zhao, Zhangyan, Wu, Qingguo, Song, Shu, Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345009/
https://www.ncbi.nlm.nih.gov/pubmed/34367247
http://dx.doi.org/10.3389/fgene.2021.689097
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author Tang, Haicheng
Pang, Pei
Qin, Zhu
Zhao, Zhangyan
Wu, Qingguo
Song, Shu
Li, Feng
author_facet Tang, Haicheng
Pang, Pei
Qin, Zhu
Zhao, Zhangyan
Wu, Qingguo
Song, Shu
Li, Feng
author_sort Tang, Haicheng
collection PubMed
description Lung cancer is the leading cause of cancer-related deaths worldwide. Despite significant advances in cancer research and treatment, the overall prognosis of lung cancer patients remains poor. Therefore, the identification for novel therapeutic targets is critical for the diagnosis and treatment of lung cancer. CPNEs (copines) are a family of membrane-bound proteins that are highly conserved, soluble, ubiquitous, calcium dependent in a variety of eukaryotes. Emerging evidences have also indicated CPNE family members are involved in cancer development and progression as well. However, the expression patterns and clinical roles in cancer have not yet been well understood. In this review, we summarize recent advances concerning CPNE family members and provide insights into new potential mechanism involved in cancer development.
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spelling pubmed-83450092021-08-07 The CPNE Family and Their Role in Cancers Tang, Haicheng Pang, Pei Qin, Zhu Zhao, Zhangyan Wu, Qingguo Song, Shu Li, Feng Front Genet Genetics Lung cancer is the leading cause of cancer-related deaths worldwide. Despite significant advances in cancer research and treatment, the overall prognosis of lung cancer patients remains poor. Therefore, the identification for novel therapeutic targets is critical for the diagnosis and treatment of lung cancer. CPNEs (copines) are a family of membrane-bound proteins that are highly conserved, soluble, ubiquitous, calcium dependent in a variety of eukaryotes. Emerging evidences have also indicated CPNE family members are involved in cancer development and progression as well. However, the expression patterns and clinical roles in cancer have not yet been well understood. In this review, we summarize recent advances concerning CPNE family members and provide insights into new potential mechanism involved in cancer development. Frontiers Media S.A. 2021-07-23 /pmc/articles/PMC8345009/ /pubmed/34367247 http://dx.doi.org/10.3389/fgene.2021.689097 Text en Copyright © 2021 Tang, Pang, Qin, Zhao, Wu, Song and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Tang, Haicheng
Pang, Pei
Qin, Zhu
Zhao, Zhangyan
Wu, Qingguo
Song, Shu
Li, Feng
The CPNE Family and Their Role in Cancers
title The CPNE Family and Their Role in Cancers
title_full The CPNE Family and Their Role in Cancers
title_fullStr The CPNE Family and Their Role in Cancers
title_full_unstemmed The CPNE Family and Their Role in Cancers
title_short The CPNE Family and Their Role in Cancers
title_sort cpne family and their role in cancers
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345009/
https://www.ncbi.nlm.nih.gov/pubmed/34367247
http://dx.doi.org/10.3389/fgene.2021.689097
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