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Optimization of New Catalytic Topoisomerase II Inhibitors as an Anti-Cancer Therapy
SIMPLE SUMMARY: DNA topoisomerase II (TOP2) is a drug target for many types of cancers. However, clinically used TOP2 inhibitors not only kill cancer cells, but also damage normal cells, and can even give rise to other types of cancers. To discover new TOP2 inhibitors to more effectively treat cance...
Autores principales: | Matias-Barrios, Victor M., Radaeva, Mariia, Ho, Chia-Hao, Lee, Joseph, Adomat, Hans, Lallous, Nada, Cherkasov, Artem, Dong, Xuesen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345109/ https://www.ncbi.nlm.nih.gov/pubmed/34359577 http://dx.doi.org/10.3390/cancers13153675 |
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