Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition

SIMPLE SUMMARY: Functionality of the cellular DNA damage response (DDR) network affects risk for developing cancer, and the DDR is also a target of cancer therapies. Thus, it is important that we have reliable laboratory methods for determining the activity of this network. We describe the developme...

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Detalles Bibliográficos
Autores principales: Whiteaker, Jeffrey R., Wang, Tao, Zhao, Lei, Schoenherr, Regine M., Kennedy, Jacob J., Voytovich, Ulianna, Ivey, Richard G., Huang, Dongqing, Lin, Chenwei, Colantonio, Simona, Caceres, Tessa W., Roberts, Rhonda R., Knotts, Joseph G., Kaczmarczyk, Jan A., Blonder, Josip, Reading, Joshua J., Richardson, Christopher W., Hewitt, Stephen M., Garcia-Buntley, Sandra S., Bocik, William, Hiltke, Tara, Rodriguez, Henry, Harrington, Elizabeth A., Barrett, J. Carl, Lombardi, Benedetta, Marco-Casanova, Paola, Pierce, Andrew J., Paulovich, Amanda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345163/
https://www.ncbi.nlm.nih.gov/pubmed/34359745
http://dx.doi.org/10.3390/cancers13153843

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