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Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

Cerebral small vessel disease (SVD) is a leading cause of vascular cognitive impairment, however the precise nature of SVD-related cognitive deficits, and their associations with structural brain changes, remain unclear. We combined computational volumes and visually-rated MRI markers of SVD to quan...

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Autores principales: Hamilton, OKL, Cox, SR, Ballerini, L, Bastin, ME, Corley, J, Gow, AJ, Muñoz Maniega, S, Redmond, P, Valdés Hernández, M del C, Wardlaw, JM, Deary, IJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345313/
https://www.ncbi.nlm.nih.gov/pubmed/34022536
http://dx.doi.org/10.1016/j.neurobiolaging.2021.04.007
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author Hamilton, OKL
Cox, SR
Ballerini, L
Bastin, ME
Corley, J
Gow, AJ
Muñoz Maniega, S
Redmond, P
Valdés Hernández, M del C
Wardlaw, JM
Deary, IJ
author_facet Hamilton, OKL
Cox, SR
Ballerini, L
Bastin, ME
Corley, J
Gow, AJ
Muñoz Maniega, S
Redmond, P
Valdés Hernández, M del C
Wardlaw, JM
Deary, IJ
author_sort Hamilton, OKL
collection PubMed
description Cerebral small vessel disease (SVD) is a leading cause of vascular cognitive impairment, however the precise nature of SVD-related cognitive deficits, and their associations with structural brain changes, remain unclear. We combined computational volumes and visually-rated MRI markers of SVD to quantify total SVD burden, using data from the Lothian Birth Cohort 1936 (n = 540; age: 72.6 ± 0.7 years). We found negative associations between total SVD burden and general cognitive ability (standardized β: -0.363; 95%CI: [-0.49, -0.23]; p((FDR)) < 0.001), processing speed (-0.371 [-0.50, -0.24]; p((FDR)) < 0.001), verbal memory (-0.265; [-0.42, -0.11]; p((FDR)) = 0.002), and visuospatial ability (-0.170; [-0.32, -0.02]; p((FDR)) = 0.029). Only the association between SVD burden and processing speed remained after accounting for covariance with general cognitive ability (-0.325; [-0.61, -0.04]; p((FDR)) = 0.029). This suggests that SVD's association with poorer processing speed is not driven by, but is independent of its association with poorer general cognitive ability. Tests of processing speed may be particularly sensitive to the cognitive impact of SVD, but all major cognitive domains should be tested to determine the full range of SVD-related cognitive characteristics.
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spelling pubmed-83453132021-09-01 Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort Hamilton, OKL Cox, SR Ballerini, L Bastin, ME Corley, J Gow, AJ Muñoz Maniega, S Redmond, P Valdés Hernández, M del C Wardlaw, JM Deary, IJ Neurobiol Aging Article Cerebral small vessel disease (SVD) is a leading cause of vascular cognitive impairment, however the precise nature of SVD-related cognitive deficits, and their associations with structural brain changes, remain unclear. We combined computational volumes and visually-rated MRI markers of SVD to quantify total SVD burden, using data from the Lothian Birth Cohort 1936 (n = 540; age: 72.6 ± 0.7 years). We found negative associations between total SVD burden and general cognitive ability (standardized β: -0.363; 95%CI: [-0.49, -0.23]; p((FDR)) < 0.001), processing speed (-0.371 [-0.50, -0.24]; p((FDR)) < 0.001), verbal memory (-0.265; [-0.42, -0.11]; p((FDR)) = 0.002), and visuospatial ability (-0.170; [-0.32, -0.02]; p((FDR)) = 0.029). Only the association between SVD burden and processing speed remained after accounting for covariance with general cognitive ability (-0.325; [-0.61, -0.04]; p((FDR)) = 0.029). This suggests that SVD's association with poorer processing speed is not driven by, but is independent of its association with poorer general cognitive ability. Tests of processing speed may be particularly sensitive to the cognitive impact of SVD, but all major cognitive domains should be tested to determine the full range of SVD-related cognitive characteristics. Elsevier 2021-09 /pmc/articles/PMC8345313/ /pubmed/34022536 http://dx.doi.org/10.1016/j.neurobiolaging.2021.04.007 Text en © 2021 The Author(s). Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hamilton, OKL
Cox, SR
Ballerini, L
Bastin, ME
Corley, J
Gow, AJ
Muñoz Maniega, S
Redmond, P
Valdés Hernández, M del C
Wardlaw, JM
Deary, IJ
Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort
title Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort
title_full Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort
title_fullStr Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort
title_full_unstemmed Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort
title_short Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort
title_sort associations between total mri-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345313/
https://www.ncbi.nlm.nih.gov/pubmed/34022536
http://dx.doi.org/10.1016/j.neurobiolaging.2021.04.007
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