Cargando…
Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population
INTRODUCTION: End‐stage renal disease (ESRD) is an abnormality where the kidneys are not usually working. This case‐control study was planned to determine the extent of serum lipid peroxidation, non‐enzymatic antioxidant (vitamin c), and trace elements in 50 patients with ESRD as cases and 50 normal...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345328/ https://www.ncbi.nlm.nih.gov/pubmed/34401525 http://dx.doi.org/10.1002/hsr2.348 |
_version_ | 1783734599945289728 |
---|---|
author | Hossain, Md. Shohel Amin, Mohammad Nurul Das, Abhijit Khan, A. K. M. Jahirul Hossain Sohel, Md Ahmed, Jamiuddin Islam, Md. Monirul Hossain, Md. Shahadat Rahman, Md. Masudur Nesa, Mst. Luthfun Islam, Mohammad Safiqul |
author_facet | Hossain, Md. Shohel Amin, Mohammad Nurul Das, Abhijit Khan, A. K. M. Jahirul Hossain Sohel, Md Ahmed, Jamiuddin Islam, Md. Monirul Hossain, Md. Shahadat Rahman, Md. Masudur Nesa, Mst. Luthfun Islam, Mohammad Safiqul |
author_sort | Hossain, Md. Shohel |
collection | PubMed |
description | INTRODUCTION: End‐stage renal disease (ESRD) is an abnormality where the kidneys are not usually working. This case‐control study was planned to determine the extent of serum lipid peroxidation, non‐enzymatic antioxidant (vitamin c), and trace elements in 50 patients with ESRD as cases and 50 normal healthy individuals as controls. METHODS: Determination of lipid peroxidation was carried out by ascertaining concentration of malondialdehyde (MDA) and vitamin C in serum using UV spectrophotometry whereas atomic absorption spectroscopy was used for trace elements estimation. The statistical analysis was conducted via the independent t‐test samples and Pearson correlation test. RESULTS: The blood serum study has shown substantially higher MDA values than the control level and lowers vitamin C levels in the patient population (P < .001). A negative correlation was found between the vitamin C in serum with BMI and MDA for both patients (r = −0.017 and r = −0.132, respectively) and the control group (r = −0.014 and r = −0.229, respectively) after Pearson's correlation analysis. Regarding trace elements, significantly (P < .001) lower concentrations of zinc, copper, and manganese were found in the patient group than control subjects. Inter‐element‐relationship established a strong positive harmonization between these studied elements in both the cases of patients and control subjects. CONCLUSION: Our results indicate strong associations of the pathogenesis of ESRD with depleted non‐enzymatic antioxidant, increased lipid peroxidation, and inconsistency in trace elements concentration in serum, which may provide a prognostic tool for the treatment of this concerning the disease. |
format | Online Article Text |
id | pubmed-8345328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83453282021-08-15 Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population Hossain, Md. Shohel Amin, Mohammad Nurul Das, Abhijit Khan, A. K. M. Jahirul Hossain Sohel, Md Ahmed, Jamiuddin Islam, Md. Monirul Hossain, Md. Shahadat Rahman, Md. Masudur Nesa, Mst. Luthfun Islam, Mohammad Safiqul Health Sci Rep Research Articles INTRODUCTION: End‐stage renal disease (ESRD) is an abnormality where the kidneys are not usually working. This case‐control study was planned to determine the extent of serum lipid peroxidation, non‐enzymatic antioxidant (vitamin c), and trace elements in 50 patients with ESRD as cases and 50 normal healthy individuals as controls. METHODS: Determination of lipid peroxidation was carried out by ascertaining concentration of malondialdehyde (MDA) and vitamin C in serum using UV spectrophotometry whereas atomic absorption spectroscopy was used for trace elements estimation. The statistical analysis was conducted via the independent t‐test samples and Pearson correlation test. RESULTS: The blood serum study has shown substantially higher MDA values than the control level and lowers vitamin C levels in the patient population (P < .001). A negative correlation was found between the vitamin C in serum with BMI and MDA for both patients (r = −0.017 and r = −0.132, respectively) and the control group (r = −0.014 and r = −0.229, respectively) after Pearson's correlation analysis. Regarding trace elements, significantly (P < .001) lower concentrations of zinc, copper, and manganese were found in the patient group than control subjects. Inter‐element‐relationship established a strong positive harmonization between these studied elements in both the cases of patients and control subjects. CONCLUSION: Our results indicate strong associations of the pathogenesis of ESRD with depleted non‐enzymatic antioxidant, increased lipid peroxidation, and inconsistency in trace elements concentration in serum, which may provide a prognostic tool for the treatment of this concerning the disease. John Wiley and Sons Inc. 2021-08-06 /pmc/articles/PMC8345328/ /pubmed/34401525 http://dx.doi.org/10.1002/hsr2.348 Text en © 2021 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Hossain, Md. Shohel Amin, Mohammad Nurul Das, Abhijit Khan, A. K. M. Jahirul Hossain Sohel, Md Ahmed, Jamiuddin Islam, Md. Monirul Hossain, Md. Shahadat Rahman, Md. Masudur Nesa, Mst. Luthfun Islam, Mohammad Safiqul Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population |
title | Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population |
title_full | Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population |
title_fullStr | Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population |
title_full_unstemmed | Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population |
title_short | Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population |
title_sort | increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with bangladeshi end‐stage renal disease population |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345328/ https://www.ncbi.nlm.nih.gov/pubmed/34401525 http://dx.doi.org/10.1002/hsr2.348 |
work_keys_str_mv | AT hossainmdshohel increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation AT aminmohammadnurul increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation AT dasabhijit increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation AT khanakmjahirulhossain increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation AT sohelmd increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation AT ahmedjamiuddin increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation AT islammdmonirul increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation AT hossainmdshahadat increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation AT rahmanmdmasudur increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation AT nesamstluthfun increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation AT islammohammadsafiqul increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation |