Cargando…

Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population

INTRODUCTION: End‐stage renal disease (ESRD) is an abnormality where the kidneys are not usually working. This case‐control study was planned to determine the extent of serum lipid peroxidation, non‐enzymatic antioxidant (vitamin c), and trace elements in 50 patients with ESRD as cases and 50 normal...

Descripción completa

Detalles Bibliográficos
Autores principales: Hossain, Md. Shohel, Amin, Mohammad Nurul, Das, Abhijit, Khan, A. K. M. Jahirul Hossain, Sohel, Md, Ahmed, Jamiuddin, Islam, Md. Monirul, Hossain, Md. Shahadat, Rahman, Md. Masudur, Nesa, Mst. Luthfun, Islam, Mohammad Safiqul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345328/
https://www.ncbi.nlm.nih.gov/pubmed/34401525
http://dx.doi.org/10.1002/hsr2.348
_version_ 1783734599945289728
author Hossain, Md. Shohel
Amin, Mohammad Nurul
Das, Abhijit
Khan, A. K. M. Jahirul Hossain
Sohel, Md
Ahmed, Jamiuddin
Islam, Md. Monirul
Hossain, Md. Shahadat
Rahman, Md. Masudur
Nesa, Mst. Luthfun
Islam, Mohammad Safiqul
author_facet Hossain, Md. Shohel
Amin, Mohammad Nurul
Das, Abhijit
Khan, A. K. M. Jahirul Hossain
Sohel, Md
Ahmed, Jamiuddin
Islam, Md. Monirul
Hossain, Md. Shahadat
Rahman, Md. Masudur
Nesa, Mst. Luthfun
Islam, Mohammad Safiqul
author_sort Hossain, Md. Shohel
collection PubMed
description INTRODUCTION: End‐stage renal disease (ESRD) is an abnormality where the kidneys are not usually working. This case‐control study was planned to determine the extent of serum lipid peroxidation, non‐enzymatic antioxidant (vitamin c), and trace elements in 50 patients with ESRD as cases and 50 normal healthy individuals as controls. METHODS: Determination of lipid peroxidation was carried out by ascertaining concentration of malondialdehyde (MDA) and vitamin C in serum using UV spectrophotometry whereas atomic absorption spectroscopy was used for trace elements estimation. The statistical analysis was conducted via the independent t‐test samples and Pearson correlation test. RESULTS: The blood serum study has shown substantially higher MDA values than the control level and lowers vitamin C levels in the patient population (P < .001). A negative correlation was found between the vitamin C in serum with BMI and MDA for both patients (r = −0.017 and r = −0.132, respectively) and the control group (r = −0.014 and r = −0.229, respectively) after Pearson's correlation analysis. Regarding trace elements, significantly (P < .001) lower concentrations of zinc, copper, and manganese were found in the patient group than control subjects. Inter‐element‐relationship established a strong positive harmonization between these studied elements in both the cases of patients and control subjects. CONCLUSION: Our results indicate strong associations of the pathogenesis of ESRD with depleted non‐enzymatic antioxidant, increased lipid peroxidation, and inconsistency in trace elements concentration in serum, which may provide a prognostic tool for the treatment of this concerning the disease.
format Online
Article
Text
id pubmed-8345328
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-83453282021-08-15 Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population Hossain, Md. Shohel Amin, Mohammad Nurul Das, Abhijit Khan, A. K. M. Jahirul Hossain Sohel, Md Ahmed, Jamiuddin Islam, Md. Monirul Hossain, Md. Shahadat Rahman, Md. Masudur Nesa, Mst. Luthfun Islam, Mohammad Safiqul Health Sci Rep Research Articles INTRODUCTION: End‐stage renal disease (ESRD) is an abnormality where the kidneys are not usually working. This case‐control study was planned to determine the extent of serum lipid peroxidation, non‐enzymatic antioxidant (vitamin c), and trace elements in 50 patients with ESRD as cases and 50 normal healthy individuals as controls. METHODS: Determination of lipid peroxidation was carried out by ascertaining concentration of malondialdehyde (MDA) and vitamin C in serum using UV spectrophotometry whereas atomic absorption spectroscopy was used for trace elements estimation. The statistical analysis was conducted via the independent t‐test samples and Pearson correlation test. RESULTS: The blood serum study has shown substantially higher MDA values than the control level and lowers vitamin C levels in the patient population (P < .001). A negative correlation was found between the vitamin C in serum with BMI and MDA for both patients (r = −0.017 and r = −0.132, respectively) and the control group (r = −0.014 and r = −0.229, respectively) after Pearson's correlation analysis. Regarding trace elements, significantly (P < .001) lower concentrations of zinc, copper, and manganese were found in the patient group than control subjects. Inter‐element‐relationship established a strong positive harmonization between these studied elements in both the cases of patients and control subjects. CONCLUSION: Our results indicate strong associations of the pathogenesis of ESRD with depleted non‐enzymatic antioxidant, increased lipid peroxidation, and inconsistency in trace elements concentration in serum, which may provide a prognostic tool for the treatment of this concerning the disease. John Wiley and Sons Inc. 2021-08-06 /pmc/articles/PMC8345328/ /pubmed/34401525 http://dx.doi.org/10.1002/hsr2.348 Text en © 2021 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Hossain, Md. Shohel
Amin, Mohammad Nurul
Das, Abhijit
Khan, A. K. M. Jahirul Hossain
Sohel, Md
Ahmed, Jamiuddin
Islam, Md. Monirul
Hossain, Md. Shahadat
Rahman, Md. Masudur
Nesa, Mst. Luthfun
Islam, Mohammad Safiqul
Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population
title Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population
title_full Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population
title_fullStr Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population
title_full_unstemmed Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population
title_short Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population
title_sort increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with bangladeshi end‐stage renal disease population
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345328/
https://www.ncbi.nlm.nih.gov/pubmed/34401525
http://dx.doi.org/10.1002/hsr2.348
work_keys_str_mv AT hossainmdshohel increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation
AT aminmohammadnurul increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation
AT dasabhijit increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation
AT khanakmjahirulhossain increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation
AT sohelmd increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation
AT ahmedjamiuddin increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation
AT islammdmonirul increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation
AT hossainmdshahadat increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation
AT rahmanmdmasudur increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation
AT nesamstluthfun increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation
AT islammohammadsafiqul increasedlipidperoxidationdepletednonenzymaticantioxidantandvariabilityintraceelementsconcentrationinserumarecorrelatedwithbangladeshiendstagerenaldiseasepopulation