Cargando…

The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan

We evaluated the association between urinary cadmium concentration (uCd, μg/g Cr) and risk of cause-specific mortality according to urinary β2-microglobulin (MG) concentration. Participants were 1383 male and 1700 female inhabitants of the Cd-polluted Kakehashi River basin. The uCd and β2-MG were ev...

Descripción completa

Detalles Bibliográficos
Autores principales: Sakurai, Masaru, Suwazono, Yasushi, Nishijo, Muneko, Nogawa, Kazuhiro, Watanabe, Yuuka, Yoneda, Kazuka, Ishizaki, Masao, Morikawa, Yuko, Kido, Teruhiko, Nakagawa, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345790/
https://www.ncbi.nlm.nih.gov/pubmed/34360038
http://dx.doi.org/10.3390/ijerph18157747
_version_ 1783734714132070400
author Sakurai, Masaru
Suwazono, Yasushi
Nishijo, Muneko
Nogawa, Kazuhiro
Watanabe, Yuuka
Yoneda, Kazuka
Ishizaki, Masao
Morikawa, Yuko
Kido, Teruhiko
Nakagawa, Hideaki
author_facet Sakurai, Masaru
Suwazono, Yasushi
Nishijo, Muneko
Nogawa, Kazuhiro
Watanabe, Yuuka
Yoneda, Kazuka
Ishizaki, Masao
Morikawa, Yuko
Kido, Teruhiko
Nakagawa, Hideaki
author_sort Sakurai, Masaru
collection PubMed
description We evaluated the association between urinary cadmium concentration (uCd, μg/g Cr) and risk of cause-specific mortality according to urinary β2-microglobulin (MG) concentration. Participants were 1383 male and 1700 female inhabitants of the Cd-polluted Kakehashi River basin. The uCd and β2-MG were evaluated in a survey in 1981–1982, where those participants were followed-up over 35 years later. Among the participants with a urinary β2-MG < 1000, the hazard ratios (HRs) (95% confidence interval) for mortality were significantly higher in those with a uCd of ≥10.0 compared with <5.0 for cardiovascular disease [HR 1.92 (1.08–3.40) for men, 1.71 (1.07–2.71) for women], pneumonia or influenza [2.10 (1.10–4.00) for men, 2.22 (1.17–4.19) for women], and digestive diseases [for men; 3.81 (1.49–9.74)]. The uCd was significantly associated with mortality from heart failure in women and digestive diseases in men, after adjustment for other causes of death using the Fine and Gray competing risk regression model. For participants with a urinary β2-MG of ≥1000, no significant association was observed between uCd and any major cause of death. In the absence of kidney damage, Cd may increase the risk of death from cardiovascular disease, pneumonia, and digestive diseases.
format Online
Article
Text
id pubmed-8345790
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83457902021-08-07 The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan Sakurai, Masaru Suwazono, Yasushi Nishijo, Muneko Nogawa, Kazuhiro Watanabe, Yuuka Yoneda, Kazuka Ishizaki, Masao Morikawa, Yuko Kido, Teruhiko Nakagawa, Hideaki Int J Environ Res Public Health Article We evaluated the association between urinary cadmium concentration (uCd, μg/g Cr) and risk of cause-specific mortality according to urinary β2-microglobulin (MG) concentration. Participants were 1383 male and 1700 female inhabitants of the Cd-polluted Kakehashi River basin. The uCd and β2-MG were evaluated in a survey in 1981–1982, where those participants were followed-up over 35 years later. Among the participants with a urinary β2-MG < 1000, the hazard ratios (HRs) (95% confidence interval) for mortality were significantly higher in those with a uCd of ≥10.0 compared with <5.0 for cardiovascular disease [HR 1.92 (1.08–3.40) for men, 1.71 (1.07–2.71) for women], pneumonia or influenza [2.10 (1.10–4.00) for men, 2.22 (1.17–4.19) for women], and digestive diseases [for men; 3.81 (1.49–9.74)]. The uCd was significantly associated with mortality from heart failure in women and digestive diseases in men, after adjustment for other causes of death using the Fine and Gray competing risk regression model. For participants with a urinary β2-MG of ≥1000, no significant association was observed between uCd and any major cause of death. In the absence of kidney damage, Cd may increase the risk of death from cardiovascular disease, pneumonia, and digestive diseases. MDPI 2021-07-21 /pmc/articles/PMC8345790/ /pubmed/34360038 http://dx.doi.org/10.3390/ijerph18157747 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sakurai, Masaru
Suwazono, Yasushi
Nishijo, Muneko
Nogawa, Kazuhiro
Watanabe, Yuuka
Yoneda, Kazuka
Ishizaki, Masao
Morikawa, Yuko
Kido, Teruhiko
Nakagawa, Hideaki
The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan
title The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan
title_full The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan
title_fullStr The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan
title_full_unstemmed The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan
title_short The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan
title_sort relationship between the urinary cadmium concentration and cause-specific mortality in subjects without severe renal damage: a 35-year follow-up study in a cadmium-polluted area of japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345790/
https://www.ncbi.nlm.nih.gov/pubmed/34360038
http://dx.doi.org/10.3390/ijerph18157747
work_keys_str_mv AT sakuraimasaru therelationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT suwazonoyasushi therelationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT nishijomuneko therelationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT nogawakazuhiro therelationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT watanabeyuuka therelationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT yonedakazuka therelationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT ishizakimasao therelationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT morikawayuko therelationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT kidoteruhiko therelationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT nakagawahideaki therelationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT sakuraimasaru relationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT suwazonoyasushi relationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT nishijomuneko relationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT nogawakazuhiro relationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT watanabeyuuka relationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT yonedakazuka relationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT ishizakimasao relationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT morikawayuko relationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT kidoteruhiko relationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan
AT nakagawahideaki relationshipbetweentheurinarycadmiumconcentrationandcausespecificmortalityinsubjectswithoutsevererenaldamagea35yearfollowupstudyinacadmiumpollutedareaofjapan