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Ras/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells

The TMPRSS2/ERG gene rearrangement occurs in 50% of prostate tumors and results in expression of the transcription factor ERG, which is normally silent in prostate cells. ERG expression promotes prostate tumor formation and luminal epithelial cell fates when combined with PI3K/AKT pathway activation...

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Detalles Bibliográficos
Autores principales:	Strittmatter, Brady G., Jerde, Travis J., Hollenhorst, Peter C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345871/ https://www.ncbi.nlm.nih.gov/pubmed/34314419 http://dx.doi.org/10.1371/journal.pgen.1009708

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