CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD

The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. This requires the Nedd4 family HECT E3 ubiquitin ligase Wwp2 and a tumor-suppressing trans...

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Detalles Bibliográficos
Autores principales: Cerny, Ondrej, Godlee, Camilla, Tocci, Romina, Cross, Nancy E., Shi, Haoran, Williamson, James C., Alix, Eric, Lehner, Paul J., Holden, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345877/
https://www.ncbi.nlm.nih.gov/pubmed/34314469
http://dx.doi.org/10.1371/journal.ppat.1009771

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