Modeling Na(V)1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine

Loss of function mutations of SCN1A, the gene coding for the voltage-gated sodium channel Na(V)1.1, cause different types of epilepsy, whereas gain of function mutations cause sporadic and familial hemiplegic migraine type 3 (FHM-3). However, it is not clear yet how these opposite effects can induce...

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Detalles Bibliográficos
Autores principales: Lemaire, Louisiane, Desroches, Mathieu, Krupa, Martin, Pizzamiglio, Lara, Scalmani, Paolo, Mantegazza, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345895/
https://www.ncbi.nlm.nih.gov/pubmed/34314446
http://dx.doi.org/10.1371/journal.pcbi.1009239

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