Cargando…

The Sodium-Glucose Cotransporter-2 Inhibitor Canagliflozin Alleviates Endothelial Dysfunction Following In Vitro Vascular Ischemia/Reperfusion Injury in Rats

Vascular ischemia/reperfusion injury (IRI) contributes to graft failure and adverse clinical outcomes following coronary artery bypass grafting. Sodium-glucose-cotransporter (SGLT)-2-inhibitors have been shown to protect against myocardial IRI, irrespective of diabetes. We hypothesized that adding c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Korkmaz-Icöz, Sevil, Kocer, Cenk, Sayour, Alex A., Kraft, Patricia, Benker, Mona I., Abulizi, Sophia, Georgevici, Adrian-Iustin, Brlecic, Paige, Radovits, Tamás, Loganathan, Sivakkanan, Karck, Matthias, Szabó, Gábor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345991/ https://www.ncbi.nlm.nih.gov/pubmed/34360539 http://dx.doi.org/10.3390/ijms22157774

Ejemplares similares

Bone Marrow Culture-Derived Conditioned Medium Recovers Endothelial Function of Vascular Grafts following In Vitro Ischemia/Reperfusion Injury in Diabetic Rats
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2022)

Conditioned Medium from Mesenchymal Stem Cells Alleviates Endothelial Dysfunction of Vascular Grafts Submitted to Ischemia/Reperfusion Injury in 15-Month-Old Rats
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2021)

Mesenchymal stem cell-derived conditioned medium protects vascular grafts of brain-dead rats against in vitro ischemia/reperfusion injury
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2021)

Preservation solution Custodiol containing human alpha-1-antitrypsin improves graft recovery after prolonged cold ischemic storage in a rat model of heart transplantation
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2023)

Left-ventricular hypertrophy in 18-month-old donor rat hearts was not associated with graft dysfunction in the early phase of reperfusion after cardiac transplantation–gene expression profiling
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2021)

Graft Preservation Solution DuraGraft(®) Alleviates Vascular Dysfunction Following In Vitro Ischemia/Reperfusion Injury in Rats
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2021)

Acute canagliflozin treatment protects against in vivo myocardial ischemia–reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation
por: Sayour, Alex Ali, et al.
Publicado: (2019)

Improvement of Left Ventricular Graft Function Using an Iron-Chelator-Supplemented Bretschneider Solution in a Canine Model of Orthotopic Heart Transplantation
por: Szabó, Gábor, et al.
Publicado: (2022)

Aspirin Reduces Ischemia-Reperfusion Injury Induced Endothelial Cell Damage of Arterial Grafts in a Rodent Model
por: Veres, Gábor, et al.
Publicado: (2022)

Pharmacological preconditioning with the guanylate cyclase activator cinaciguat (BAY 58-2667) protects against reperfusion injury after cardiopulmonary bypass
por: Radovits, Tamás, et al.
Publicado: (2009)

Phosphodiesterase-5 inhibition delays cardiac dilation and improves myocardial function in a rat model of heart failure due to chronic volume overload
por: Loganathan, Sivakkanan, et al.
Publicado: (2009)

Mild Type 2 Diabetes Mellitus Reduces the Susceptibility of the Heart to Ischemia/Reperfusion Injury: Identification of Underlying Gene Expression Changes
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2015)

Comparison of donor hearts from hypoxic cardiac arrest followed by warm ischemia and from exsanguination as non-beating donor models in rat heart transplantation
por: Li, Shiliang, et al.
Publicado: (2015)

Comparison of the Reverse-Remodeling Effect of Pharmacological Soluble Guanylate Cyclase Activation With Pressure Unloading in Pathological Myocardial Left Ventricular Hypertrophy
por: Ruppert, Mihály, et al.
Publicado: (2019)

Improving Diastolic and Microvascular Function in Heart Transplantation with Donation after Circulatory Death
por: Saemann, Lars, et al.
Publicado: (2023)

Pharmacological activation of soluble guanylate cyclase activator protects the heart against isoproterenol-induced myocardial ischemia in rats
por: Korkmaz, Sevil, et al.
Publicado: (2009)

Acute Ethanol Exposure Increases the Susceptibility of the Donor Hearts to Ischemia/Reperfusion Injury after Transplantation in Rats
por: Li, Shiliang, et al.
Publicado: (2012)

Cytokine Adsorber Use during DCD Heart Perfusion Counteracts Coronary Microvascular Dysfunction
por: Saemann, Lars, et al.
Publicado: (2022)

Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats
por: Liu, Baoer, et al.
Publicado: (2023)

Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2016)

Ethical Decision Diagrams on Donation After Cardiocirculatory Death Heart Transplantation Considering Organ Preservation Techniques
por: Saemann, Lars, et al.
Publicado: (2020)

Endothelial Dysfunction of Bypass Graft: Direct Comparison of In Vitro and In Vivo Models of Ischemia-Reperfusion Injury
por: Veres, Gábor, et al.
Publicado: (2015)

Pressure overload-induced systolic heart failure is associated with characteristic myocardial microRNA expression signature and post-transcriptional gene regulation in male rats
por: Ruppert, Mihály, et al.
Publicado: (2023)

Custodiol-N, the novel cardioplegic solution reduces ischemia/reperfusion injury after cardiopulmonary bypass
por: Veres, Gábor, et al.
Publicado: (2015)

Effects of inosine on reperfusion injury after cardiopulmonary bypass
por: Veres, Gábor, et al.
Publicado: (2010)

An Altered Pattern of Myocardial Histopathological and Molecular Changes Underlies the Different Characteristics of Type-1 and Type-2 Diabetic Cardiac Dysfunction
por: Radovits, Tamás, et al.
Publicado: (2015)

Negative drift of sedation depth in critically ill patients receiving constant minimum alveolar concentration of isoflurane, sevoflurane, or desflurane: a randomized controlled trial
por: Georgevici, Adrian-Iustin, et al.
Publicado: (2021)

Stimulation of soluble guanylate cyclase improves donor organ function in rat heart transplantation
por: Benke, Kálmán, et al.
Publicado: (2020)

Sodium–glucose cotransporter 2 inhibitors reduce myocardial infarct size in preclinical animal models of myocardial ischaemia–reperfusion injury: a meta-analysis
por: Sayour, Alex Ali, et al.
Publicado: (2021)

Tiprotec preserves endothelial function after cold ischemia and warm reperfusion: comparison between Saline, Custodiol and Tiprotec
por: Gábor, Veres, et al.
Publicado: (2015)

Prediction Model for Contractile Function of Circulatory Death Donor Hearts Based on Microvascular Flow Shifts During Ex Situ Hypothermic Cardioplegic Machine Perfusion
por: Saemann, Lars, et al.
Publicado: (2022)

The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus
por: Mátyás, Csaba, et al.
Publicado: (2015)

Characterization of left ventricular myocardial sodium-glucose cotransporter 1 expression in patients with end-stage heart failure
por: Sayour, Alex Ali, et al.
Publicado: (2020)

Euglycemic Diabetic Ketoacidosis With Prolonged Glucosuria Associated With the Sodium-Glucose Cotransporter-2 Canagliflozin
por: Kelmenson, Daniel A., et al.
Publicado: (2017)

Total Aortic Arch Replacement: Superior Ventriculo-Arterial Coupling with Decellularized Allografts Compared with Conventional Prostheses
por: Weymann, Alexander, et al.
Publicado: (2014)

Infusion of sodium sulfide improves myocardial and endothelial function in a canine model of cardiopulmonary bypass
por: Szabó, C, et al.
Publicado: (2007)

GMP Compliant Synthesis of [(18)F]Canagliflozin, a Novel PET Tracer for the Sodium–Glucose Cotransporter 2
por: van der Hoek, Sjoukje, et al.
Publicado: (2021)

Pharmacological preconditioning with gemfibrozil preserves cardiac function after heart transplantation
por: Benke, Kálmán, et al.
Publicado: (2017)

Dose-Ranging Effects of Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, as Add-On to Metformin in Subjects With Type 2 Diabetes
por: Rosenstock, Julio, et al.
Publicado: (2012)

Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling
por: Sokolov, Victor, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e12ooe5fqio2snooprke377dto