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Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease

The heart is the first organ to acquire its physiological function during development, enabling it to supply the organism with oxygen and nutrients. Given this early commitment, cardiomyocytes were traditionally considered transcriptionally stable cells fully committed to contractile function. Howev...

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Autores principales: Paredes, Ana, Santos-Clemente, Rocio, Ricote, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346021/
https://www.ncbi.nlm.nih.gov/pubmed/34360540
http://dx.doi.org/10.3390/ijms22157775
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author Paredes, Ana
Santos-Clemente, Rocio
Ricote, Mercedes
author_facet Paredes, Ana
Santos-Clemente, Rocio
Ricote, Mercedes
author_sort Paredes, Ana
collection PubMed
description The heart is the first organ to acquire its physiological function during development, enabling it to supply the organism with oxygen and nutrients. Given this early commitment, cardiomyocytes were traditionally considered transcriptionally stable cells fully committed to contractile function. However, growing evidence suggests that the maintenance of cardiac function in health and disease depends on transcriptional and epigenetic regulation. Several studies have revealed that the complex transcriptional alterations underlying cardiovascular disease (CVD) manifestations such as myocardial infarction and hypertrophy is mediated by cardiac retinoid X receptors (RXR) and their partners. RXRs are members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors and drive essential biological processes such as ion handling, mitochondrial biogenesis, and glucose and lipid metabolism. RXRs are thus attractive molecular targets for the development of effective pharmacological strategies for CVD treatment and prevention. In this review, we summarize current knowledge of RXR partnership biology in cardiac homeostasis and disease, providing an up-to-date view of the molecular mechanisms and cellular pathways that sustain cardiomyocyte physiology.
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spelling pubmed-83460212021-08-07 Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease Paredes, Ana Santos-Clemente, Rocio Ricote, Mercedes Int J Mol Sci Review The heart is the first organ to acquire its physiological function during development, enabling it to supply the organism with oxygen and nutrients. Given this early commitment, cardiomyocytes were traditionally considered transcriptionally stable cells fully committed to contractile function. However, growing evidence suggests that the maintenance of cardiac function in health and disease depends on transcriptional and epigenetic regulation. Several studies have revealed that the complex transcriptional alterations underlying cardiovascular disease (CVD) manifestations such as myocardial infarction and hypertrophy is mediated by cardiac retinoid X receptors (RXR) and their partners. RXRs are members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors and drive essential biological processes such as ion handling, mitochondrial biogenesis, and glucose and lipid metabolism. RXRs are thus attractive molecular targets for the development of effective pharmacological strategies for CVD treatment and prevention. In this review, we summarize current knowledge of RXR partnership biology in cardiac homeostasis and disease, providing an up-to-date view of the molecular mechanisms and cellular pathways that sustain cardiomyocyte physiology. MDPI 2021-07-21 /pmc/articles/PMC8346021/ /pubmed/34360540 http://dx.doi.org/10.3390/ijms22157775 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paredes, Ana
Santos-Clemente, Rocio
Ricote, Mercedes
Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease
title Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease
title_full Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease
title_fullStr Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease
title_full_unstemmed Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease
title_short Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease
title_sort untangling the cooperative role of nuclear receptors in cardiovascular physiology and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346021/
https://www.ncbi.nlm.nih.gov/pubmed/34360540
http://dx.doi.org/10.3390/ijms22157775
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