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Electrophysiological Characterization of Human Atria: The Understated Role of Temperature

Ambient temperature has a profound influence on cellular electrophysiology through direct control over the gating mechanisms of different ion channels. In the heart, low temperature is known to favor prolongation of the action potential. However, not much is known about the influence of temperature...

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Autores principales: Majumder, Rupamanjari, Mohamed Nazer, Afnan Nabizath, Panfilov, Alexander V., Bodenschatz, Eberhard, Wang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346027/
https://www.ncbi.nlm.nih.gov/pubmed/34366877
http://dx.doi.org/10.3389/fphys.2021.639149
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author Majumder, Rupamanjari
Mohamed Nazer, Afnan Nabizath
Panfilov, Alexander V.
Bodenschatz, Eberhard
Wang, Yong
author_facet Majumder, Rupamanjari
Mohamed Nazer, Afnan Nabizath
Panfilov, Alexander V.
Bodenschatz, Eberhard
Wang, Yong
author_sort Majumder, Rupamanjari
collection PubMed
description Ambient temperature has a profound influence on cellular electrophysiology through direct control over the gating mechanisms of different ion channels. In the heart, low temperature is known to favor prolongation of the action potential. However, not much is known about the influence of temperature on other important characterization parameters such as the resting membrane potential (RMP), excitability, morphology and characteristics of the action potential (AP), restitution properties, conduction velocity (CV) of signal propagation, etc. Here we present the first, detailed, systematic in silico study of the electrophysiological characterization of cardiomyocytes from different regions of the normal human atria, based on the effects of ambient temperature (5−50°C). We observe that RMP decreases with increasing temperature. At ~ 48°C, the cells lose their excitability. Our studies show that different parts of the atria react differently to the same changes in temperature. In tissue simulations a drop in temperature correlated positively with a decrease in CV, but the decrease was region-dependent, as expected. In this article we show how this heterogeneous response can provide an explanation for the development of a proarrhythmic substrate during mild hypothermia. We use the above concept to propose a treatment strategy for atrial fibrillation that involves severe hypothermia in specific regions of the heart for a duration of only ~ 200 ms.
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spelling pubmed-83460272021-08-07 Electrophysiological Characterization of Human Atria: The Understated Role of Temperature Majumder, Rupamanjari Mohamed Nazer, Afnan Nabizath Panfilov, Alexander V. Bodenschatz, Eberhard Wang, Yong Front Physiol Physiology Ambient temperature has a profound influence on cellular electrophysiology through direct control over the gating mechanisms of different ion channels. In the heart, low temperature is known to favor prolongation of the action potential. However, not much is known about the influence of temperature on other important characterization parameters such as the resting membrane potential (RMP), excitability, morphology and characteristics of the action potential (AP), restitution properties, conduction velocity (CV) of signal propagation, etc. Here we present the first, detailed, systematic in silico study of the electrophysiological characterization of cardiomyocytes from different regions of the normal human atria, based on the effects of ambient temperature (5−50°C). We observe that RMP decreases with increasing temperature. At ~ 48°C, the cells lose their excitability. Our studies show that different parts of the atria react differently to the same changes in temperature. In tissue simulations a drop in temperature correlated positively with a decrease in CV, but the decrease was region-dependent, as expected. In this article we show how this heterogeneous response can provide an explanation for the development of a proarrhythmic substrate during mild hypothermia. We use the above concept to propose a treatment strategy for atrial fibrillation that involves severe hypothermia in specific regions of the heart for a duration of only ~ 200 ms. Frontiers Media S.A. 2021-07-23 /pmc/articles/PMC8346027/ /pubmed/34366877 http://dx.doi.org/10.3389/fphys.2021.639149 Text en Copyright © 2021 Majumder, Mohamed Nazer, Panfilov, Bodenschatz and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Majumder, Rupamanjari
Mohamed Nazer, Afnan Nabizath
Panfilov, Alexander V.
Bodenschatz, Eberhard
Wang, Yong
Electrophysiological Characterization of Human Atria: The Understated Role of Temperature
title Electrophysiological Characterization of Human Atria: The Understated Role of Temperature
title_full Electrophysiological Characterization of Human Atria: The Understated Role of Temperature
title_fullStr Electrophysiological Characterization of Human Atria: The Understated Role of Temperature
title_full_unstemmed Electrophysiological Characterization of Human Atria: The Understated Role of Temperature
title_short Electrophysiological Characterization of Human Atria: The Understated Role of Temperature
title_sort electrophysiological characterization of human atria: the understated role of temperature
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346027/
https://www.ncbi.nlm.nih.gov/pubmed/34366877
http://dx.doi.org/10.3389/fphys.2021.639149
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