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LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?

Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as ‘rare’ due to an annual incidence of <6 per 100,000 women. The majority of these tend to be associated with a poor prognosis...

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Autores principales: Di Fiore, Riccardo, Suleiman, Sherif, Drago-Ferrante, Rosa, Felix, Ana, O’Toole, Sharon A., O’Leary, John J., Ward, Mark P., Beirne, James, Yordanov, Angel, Vasileva-Slaveva, Mariela, Subbannayya, Yashwanth, Pentimalli, Francesca, Giordano, Antonio, Calleja-Agius, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346052/
https://www.ncbi.nlm.nih.gov/pubmed/34360598
http://dx.doi.org/10.3390/ijms22157829
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author Di Fiore, Riccardo
Suleiman, Sherif
Drago-Ferrante, Rosa
Felix, Ana
O’Toole, Sharon A.
O’Leary, John J.
Ward, Mark P.
Beirne, James
Yordanov, Angel
Vasileva-Slaveva, Mariela
Subbannayya, Yashwanth
Pentimalli, Francesca
Giordano, Antonio
Calleja-Agius, Jean
author_facet Di Fiore, Riccardo
Suleiman, Sherif
Drago-Ferrante, Rosa
Felix, Ana
O’Toole, Sharon A.
O’Leary, John J.
Ward, Mark P.
Beirne, James
Yordanov, Angel
Vasileva-Slaveva, Mariela
Subbannayya, Yashwanth
Pentimalli, Francesca
Giordano, Antonio
Calleja-Agius, Jean
author_sort Di Fiore, Riccardo
collection PubMed
description Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as ‘rare’ due to an annual incidence of <6 per 100,000 women. The majority of these tend to be associated with a poor prognosis. Long non-coding RNAs (lncRNAs) play a critical role in the normal development of organisms as well as in tumorigenesis. LncRNAs can be classified into tumor suppressor genes or oncogenes, depending on their function within the cellular context and the signaling pathways in which they are involved. These regulatory RNAs are potential therapeutic targets for cancer due to their tissue and tumor specificity. However, there still needs to be a deeper understanding of the mechanisms by which lncRNAs are involved in the regulation of numerous biological functions in humans, both in normal health and disease. The lncRNA Mortal Obligate RNA Transcript (MORT; alias ZNF667-AS1) has been identified as a tumor-related lncRNA. ZNF667-AS1 gene, located in the human chromosome region 19q13.43, has been shown to be silenced by DNA hypermethylation in several cancers. In this review, we report on the biological functions of ZNF667-AS1 from recent studies and describe the regulatory functions of ZNF667-AS1 in human disease, including cancer. Furthermore, we discuss the emerging insights into the potential role of ZNF667-AS1 as a biomarker and novel therapeutic target in cancer, including GCs (ovarian, cervical, and endometrial cancers).
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spelling pubmed-83460522021-08-07 LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies? Di Fiore, Riccardo Suleiman, Sherif Drago-Ferrante, Rosa Felix, Ana O’Toole, Sharon A. O’Leary, John J. Ward, Mark P. Beirne, James Yordanov, Angel Vasileva-Slaveva, Mariela Subbannayya, Yashwanth Pentimalli, Francesca Giordano, Antonio Calleja-Agius, Jean Int J Mol Sci Review Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as ‘rare’ due to an annual incidence of <6 per 100,000 women. The majority of these tend to be associated with a poor prognosis. Long non-coding RNAs (lncRNAs) play a critical role in the normal development of organisms as well as in tumorigenesis. LncRNAs can be classified into tumor suppressor genes or oncogenes, depending on their function within the cellular context and the signaling pathways in which they are involved. These regulatory RNAs are potential therapeutic targets for cancer due to their tissue and tumor specificity. However, there still needs to be a deeper understanding of the mechanisms by which lncRNAs are involved in the regulation of numerous biological functions in humans, both in normal health and disease. The lncRNA Mortal Obligate RNA Transcript (MORT; alias ZNF667-AS1) has been identified as a tumor-related lncRNA. ZNF667-AS1 gene, located in the human chromosome region 19q13.43, has been shown to be silenced by DNA hypermethylation in several cancers. In this review, we report on the biological functions of ZNF667-AS1 from recent studies and describe the regulatory functions of ZNF667-AS1 in human disease, including cancer. Furthermore, we discuss the emerging insights into the potential role of ZNF667-AS1 as a biomarker and novel therapeutic target in cancer, including GCs (ovarian, cervical, and endometrial cancers). MDPI 2021-07-22 /pmc/articles/PMC8346052/ /pubmed/34360598 http://dx.doi.org/10.3390/ijms22157829 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Fiore, Riccardo
Suleiman, Sherif
Drago-Ferrante, Rosa
Felix, Ana
O’Toole, Sharon A.
O’Leary, John J.
Ward, Mark P.
Beirne, James
Yordanov, Angel
Vasileva-Slaveva, Mariela
Subbannayya, Yashwanth
Pentimalli, Francesca
Giordano, Antonio
Calleja-Agius, Jean
LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?
title LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?
title_full LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?
title_fullStr LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?
title_full_unstemmed LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?
title_short LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?
title_sort lncrna mort (znf667-as1) in cancer—is there a possible role in gynecological malignancies?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346052/
https://www.ncbi.nlm.nih.gov/pubmed/34360598
http://dx.doi.org/10.3390/ijms22157829
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