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Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies

Human cytosolic prolyl-tRNA synthetase (HcProRS) catalyses the formation of the prolyl-tRNA(Pro), playing an important role in protein synthesis. Inhibition of HcProRS activity has been shown to have potential benefits in the treatment of fibrosis, autoimmune diseases and cancer. Recently, potent py...

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Detalles Bibliográficos
Autores principales:	Pang, Luping, Weeks, Stephen D., Juhás, Martin, Strelkov, Sergei V., Zitko, Jan, Van Aerschot, Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346053/ https://www.ncbi.nlm.nih.gov/pubmed/34360555 http://dx.doi.org/10.3390/ijms22157793

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