Characterization of Temperature-Dependent Kinetics of Oculocutaneous Albinism-Causing Mutants of Tyrosinase

Human tyrosinase (Tyr) is a glycoenzyme that catalyzes the first and rate-limiting step in melanin production, and its gene (TYR) is mutated in many cases of oculocutaneous albinism type 1 (OCA1). The mechanisms by which individual mutations contribute to the diverse pigmentation phenotype in patien...

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Detalles Bibliográficos
Autores principales: Wachamo, Samuel A., Patel, Milan H., Varghese, Paul K., Dolinska, Monika B., Sergeev, Yuri V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346126/
https://www.ncbi.nlm.nih.gov/pubmed/34360537
http://dx.doi.org/10.3390/ijms22157771

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