Cargando…

Tumor Promoting Effect of BMP Signaling in Endometrial Cancer

The effects of bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β) family, in endometrial cancer (EC) have yet to be determined. In this study, we analyzed the TCGA and MSK-IMPACT datasets and investigated the effects of BMP2 and of TWSG1, a BMP antagonist, on Ish...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fukuda, Tomohiko, Fukuda, Risa, Miyazono, Kohei, Heldin, Carl-Henrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346149/ https://www.ncbi.nlm.nih.gov/pubmed/34360647 http://dx.doi.org/10.3390/ijms22157882

Ejemplares similares

BMP signaling is a therapeutic target in ovarian cancer
por: Fukuda, Tomohiko, et al.
Publicado: (2020)

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif
por: Morikawa, Masato, et al.
Publicado: (2011)

PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma‐initiating cell properties via DNA methyltransferase 3A
por: Tanabe, Ryo, et al.
Publicado: (2021)

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors
por: Morikawa, Masato, et al.
Publicado: (2016)

Bone morphogenetic protein signaling is a possible therapeutic target in gynecologic cancer
por: Fukuda, Tomohiko, et al.
Publicado: (2022)

Targeting the PDGF signaling pathway in tumor treatment
por: Heldin, Carl-Henrik
Publicado: (2013)

The Two-Faced Role of Autophagy in Endometrial Cancer
por: Fukuda, Tomohiko, et al.
Publicado: (2022)

Basolateral BMP Signaling in Polarized Epithelial Cells
por: Saitoh, Masao, et al.
Publicado: (2013)

TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness
por: Sundqvist, Anders, et al.
Publicado: (2020)

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion
por: Sundqvist, Anders, et al.
Publicado: (2018)

Tumor-promoting functions of transforming growth factor-β in progression of cancer
por: Miyazono, Kohei, et al.
Publicado: (2012)

2R and remodeling of vertebrate signal transduction engine
por: Huminiecki, Lukasz, et al.
Publicado: (2010)

TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling
por: Kawasaki, Natsumi, et al.
Publicado: (2018)

Neurotensin receptor 1 signaling promotes pancreatic cancer progression
por: Takahashi, Kei, et al.
Publicado: (2020)

Transforming growth factor-β signaling in epithelial-mesenchymal transition and progression of cancer
por: Miyazono, Kohei
Publicado: (2009)

Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence
por: Kaneda, Atsushi, et al.
Publicado: (2011)

HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling?
por: Herdenberg, Carl, et al.
Publicado: (2022)

Nobiletin, a NF‐κB signaling antagonist, promotes BMP‐induced bone formation
por: Rojasawasthien, Thira, et al.
Publicado: (2022)

Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years
por: Ehata, Shogo, et al.
Publicado: (2022)

CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface
por: Yakymovych, Ihor, et al.
Publicado: (2015)

Autocrine PDGF stimulation in malignancies
por: Heldin, Carl-Henrik
Publicado: (2012)

NR4A1 Promotes PDGF-BB-Induced Cell Colony Formation in Soft Agar
por: Eger, Glenda, et al.
Publicado: (2014)

Extracellular Vesicles and Transforming Growth Factor β Signaling in Cancer
por: Rodrigues-Junior, Dorival Mendes, et al.
Publicado: (2022)

TGFβ selects for pro‐stemness over pro‐invasive phenotypes during cancer cell epithelial–mesenchymal transition
por: Tsubakihara, Yutaro, et al.
Publicado: (2022)

Perirenal Abscess in a Patient with Rheumatoid Arthritis
por: Fukuda, Makoto, et al.
Publicado: (2022)

Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells
por: Caja, Laia, et al.
Publicado: (2018)

Notch signaling is necessary for epithelial growth arrest by TGF-β
por: Niimi, Hideki, et al.
Publicado: (2007)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells
por: Hou, Sicong, et al.
Publicado: (2016)

Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling
por: Husanie, Hussam, et al.
Publicado: (2022)

BMP signaling in cancer stemness and differentiation
por: Zhou, Wei, et al.
Publicado: (2023)

TRAF4 Inhibits Bladder Cancer Progression by Promoting BMP/SMAD Signaling
por: Iyengar, Prasanna Vasudevan, et al.
Publicado: (2022)

Genome-wide mechanisms of Smad binding
por: Morikawa, M, et al.
Publicado: (2013)

Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells
por: Karalis, Theodoros, et al.
Publicado: (2022)

RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma
por: Yu, Qin, et al.
Publicado: (2021)

Dynamin Inhibitors Impair Endocytosis and Mitogenic Signaling of PDGF
por: Sadowski, Łukasz, et al.
Publicado: (2013)

Autophagy inhibition augments resveratrol-induced apoptosis in Ishikawa endometrial cancer cells
por: Fukuda, Tomohiko, et al.
Publicado: (2016)

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
por: Kolliopoulos, Constantinos, et al.
Publicado: (2019)

Efp promotes in vitro and in vivo growth of endometrial cancer cells along with the activation of nuclear factor-κB signaling
por: Sato, Wataru, et al.
Publicado: (2018)

Specification of BMP Signaling
por: Nickel, Joachim, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ivabbqb6lpfj108pqvs7b48qiu