Cargando…
Electrolyte and acid-base imbalance in severe COVID-19
Acute systemic diseases, such as severe infections, can lead to electrolyte and acid-base alterations. To study the presence of electrolyte imbalance in severe COVID-19, we investigated the frequency and consequences of changes in electrolyte and acid-base patterns over time. We performed a retrospe...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346182/ https://www.ncbi.nlm.nih.gov/pubmed/34156969 http://dx.doi.org/10.1530/EC-21-0265 |
_version_ | 1783734810753105920 |
---|---|
author | Sjöström, Anna Rysz, Susanne Sjöström, Henrik Höybye, Charlotte |
author_facet | Sjöström, Anna Rysz, Susanne Sjöström, Henrik Höybye, Charlotte |
author_sort | Sjöström, Anna |
collection | PubMed |
description | Acute systemic diseases, such as severe infections, can lead to electrolyte and acid-base alterations. To study the presence of electrolyte imbalance in severe COVID-19, we investigated the frequency and consequences of changes in electrolyte and acid-base patterns over time. We performed a retrospective cohort study including 406 patients with severe COVID-19. Levels of electrolytes, base excess, pH, serum osmolality, and hematocrit, the first 2 weeks of hospitalization, were collected daily from the laboratory database and clinical data from patients’ medical records. We found that hyponatremia was present in 57% of the patients at admission and 2% in hypernatremia. However, within 2 weeks of hospitalization 42% of the patients developed hypernatremia, more frequently in critically ill patients. Lower levels of sodium and potassium during admission were associated with the need for mechanical ventilation. Decreased pH at admission was associated with both death and the need for mechanical ventilation. Hypernatremia in the ICU was combined with rising base excess and a higher pH. In the group without intensive care, potassium levels were significantly lower in the patients with severe hypernatremia. Presence of hypernatremia during the first 2 weeks of hospitalization was associated with 3.942 (95% CI 2.269–6.851) times higher odds of death. In summary, hypernatremia was common and associated with longer hospital stay and a higher risk of death, suggesting that the dynamics of sodium are an important indicator of severity in COVID-19. |
format | Online Article Text |
id | pubmed-8346182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-83461822021-08-10 Electrolyte and acid-base imbalance in severe COVID-19 Sjöström, Anna Rysz, Susanne Sjöström, Henrik Höybye, Charlotte Endocr Connect Research Acute systemic diseases, such as severe infections, can lead to electrolyte and acid-base alterations. To study the presence of electrolyte imbalance in severe COVID-19, we investigated the frequency and consequences of changes in electrolyte and acid-base patterns over time. We performed a retrospective cohort study including 406 patients with severe COVID-19. Levels of electrolytes, base excess, pH, serum osmolality, and hematocrit, the first 2 weeks of hospitalization, were collected daily from the laboratory database and clinical data from patients’ medical records. We found that hyponatremia was present in 57% of the patients at admission and 2% in hypernatremia. However, within 2 weeks of hospitalization 42% of the patients developed hypernatremia, more frequently in critically ill patients. Lower levels of sodium and potassium during admission were associated with the need for mechanical ventilation. Decreased pH at admission was associated with both death and the need for mechanical ventilation. Hypernatremia in the ICU was combined with rising base excess and a higher pH. In the group without intensive care, potassium levels were significantly lower in the patients with severe hypernatremia. Presence of hypernatremia during the first 2 weeks of hospitalization was associated with 3.942 (95% CI 2.269–6.851) times higher odds of death. In summary, hypernatremia was common and associated with longer hospital stay and a higher risk of death, suggesting that the dynamics of sodium are an important indicator of severity in COVID-19. Bioscientifica Ltd 2021-06-22 /pmc/articles/PMC8346182/ /pubmed/34156969 http://dx.doi.org/10.1530/EC-21-0265 Text en © The authors https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Sjöström, Anna Rysz, Susanne Sjöström, Henrik Höybye, Charlotte Electrolyte and acid-base imbalance in severe COVID-19 |
title | Electrolyte and acid-base imbalance in severe COVID-19 |
title_full | Electrolyte and acid-base imbalance in severe COVID-19 |
title_fullStr | Electrolyte and acid-base imbalance in severe COVID-19 |
title_full_unstemmed | Electrolyte and acid-base imbalance in severe COVID-19 |
title_short | Electrolyte and acid-base imbalance in severe COVID-19 |
title_sort | electrolyte and acid-base imbalance in severe covid-19 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346182/ https://www.ncbi.nlm.nih.gov/pubmed/34156969 http://dx.doi.org/10.1530/EC-21-0265 |
work_keys_str_mv | AT sjostromanna electrolyteandacidbaseimbalanceinseverecovid19 AT ryszsusanne electrolyteandacidbaseimbalanceinseverecovid19 AT sjostromhenrik electrolyteandacidbaseimbalanceinseverecovid19 AT hoybyecharlotte electrolyteandacidbaseimbalanceinseverecovid19 |