Cargando…

The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients

BACKGROUND: Prolonged heart rate-corrected QT (QTc) interval may reflect poor prognosis of patients with type 2 diabetes (T2D). Serum adenosine deaminase (ADA) levels are related to hyperglycemia, insulin resistance (IR) and inflammation, which may participate in diabetic complications. We investiga...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Chun-feng, Ge, Xiao-qin, Wang, Yan, Su, Jian-bin, Wang, Xue-qin, Zhang, Dong-mei, Xu, Feng, Liu, Wang-shu, Su, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346184/
https://www.ncbi.nlm.nih.gov/pubmed/34261041
http://dx.doi.org/10.1530/EC-21-0199
_version_ 1783734811237548032
author Lu, Chun-feng
Ge, Xiao-qin
Wang, Yan
Su, Jian-bin
Wang, Xue-qin
Zhang, Dong-mei
Xu, Feng
Liu, Wang-shu
Su, Min
author_facet Lu, Chun-feng
Ge, Xiao-qin
Wang, Yan
Su, Jian-bin
Wang, Xue-qin
Zhang, Dong-mei
Xu, Feng
Liu, Wang-shu
Su, Min
author_sort Lu, Chun-feng
collection PubMed
description BACKGROUND: Prolonged heart rate-corrected QT (QTc) interval may reflect poor prognosis of patients with type 2 diabetes (T2D). Serum adenosine deaminase (ADA) levels are related to hyperglycemia, insulin resistance (IR) and inflammation, which may participate in diabetic complications. We investigated the association of serum ADA levels with prolonged QTc interval in a large-scale sample of patients with T2D. METHODS: In this cross-sectional study, a total of 492 patients with T2D were recruited. Serum ADA levels were determined by venous blood during fasting. QTc interval was estimated from resting 12-lead ECGs, and prolonged QTc interval was defined as QTc > 440 ms. RESULTS: In this study, the prevalence of prolonged QTc interval was 22.8%. Serum ADA levels were positively associated with QTc interval (r = 0.324, P < 0.0001). The proportion of participants with prolonged QTc interval increased significantly from 9.2% in the first tertile (T1) to 24.7% in the second tertile (T2) and 39.0% in the third tertile (T3) of ADA (P for trend < 0.001). After adjusting for other possible risk factors by multiple linear regression analysis, serum ADA level was still significantly associated with QTc interval (β = 0.217, t = 3.400, P < 0.01). Multivariate logistic regression analysis showed that female (OR 5.084, CI 2.379–10.864, P < 0.001), insulin-sensitizers treatment (OR 4.229, CI 1.290–13.860, P = 0.017) and ADA (OR 1.212, CI 1.094–1.343, P < 0.001) were independent contributors to prolonged QTc interval. CONCLUSIONS: Serum ADA levels were independently associated with prolonged QTc interval in patients with T2D.
format Online
Article
Text
id pubmed-8346184
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Bioscientifica Ltd
record_format MEDLINE/PubMed
spelling pubmed-83461842021-08-10 The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients Lu, Chun-feng Ge, Xiao-qin Wang, Yan Su, Jian-bin Wang, Xue-qin Zhang, Dong-mei Xu, Feng Liu, Wang-shu Su, Min Endocr Connect Research BACKGROUND: Prolonged heart rate-corrected QT (QTc) interval may reflect poor prognosis of patients with type 2 diabetes (T2D). Serum adenosine deaminase (ADA) levels are related to hyperglycemia, insulin resistance (IR) and inflammation, which may participate in diabetic complications. We investigated the association of serum ADA levels with prolonged QTc interval in a large-scale sample of patients with T2D. METHODS: In this cross-sectional study, a total of 492 patients with T2D were recruited. Serum ADA levels were determined by venous blood during fasting. QTc interval was estimated from resting 12-lead ECGs, and prolonged QTc interval was defined as QTc > 440 ms. RESULTS: In this study, the prevalence of prolonged QTc interval was 22.8%. Serum ADA levels were positively associated with QTc interval (r = 0.324, P < 0.0001). The proportion of participants with prolonged QTc interval increased significantly from 9.2% in the first tertile (T1) to 24.7% in the second tertile (T2) and 39.0% in the third tertile (T3) of ADA (P for trend < 0.001). After adjusting for other possible risk factors by multiple linear regression analysis, serum ADA level was still significantly associated with QTc interval (β = 0.217, t = 3.400, P < 0.01). Multivariate logistic regression analysis showed that female (OR 5.084, CI 2.379–10.864, P < 0.001), insulin-sensitizers treatment (OR 4.229, CI 1.290–13.860, P = 0.017) and ADA (OR 1.212, CI 1.094–1.343, P < 0.001) were independent contributors to prolonged QTc interval. CONCLUSIONS: Serum ADA levels were independently associated with prolonged QTc interval in patients with T2D. Bioscientifica Ltd 2021-07-14 /pmc/articles/PMC8346184/ /pubmed/34261041 http://dx.doi.org/10.1530/EC-21-0199 Text en © The authors https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research
Lu, Chun-feng
Ge, Xiao-qin
Wang, Yan
Su, Jian-bin
Wang, Xue-qin
Zhang, Dong-mei
Xu, Feng
Liu, Wang-shu
Su, Min
The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients
title The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients
title_full The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients
title_fullStr The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients
title_full_unstemmed The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients
title_short The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients
title_sort relationship between adenosine deaminase and heart rate-corrected qt interval in type 2 diabetic patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346184/
https://www.ncbi.nlm.nih.gov/pubmed/34261041
http://dx.doi.org/10.1530/EC-21-0199
work_keys_str_mv AT luchunfeng therelationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT gexiaoqin therelationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT wangyan therelationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT sujianbin therelationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT wangxueqin therelationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT zhangdongmei therelationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT xufeng therelationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT liuwangshu therelationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT sumin therelationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT luchunfeng relationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT gexiaoqin relationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT wangyan relationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT sujianbin relationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT wangxueqin relationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT zhangdongmei relationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT xufeng relationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT liuwangshu relationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients
AT sumin relationshipbetweenadenosinedeaminaseandheartratecorrectedqtintervalintype2diabeticpatients