HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To identify splicing factors important for prostate cancer (PCa) fitness, we performed pooled shRNA screens in vitro and in vivo. Our screens id...

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Detalles Bibliográficos
Autores principales: Ho, Jessica SY, Di Tullio, Federico, Schwarz, Megan, Low, Diana, Incarnato, Danny, Gay, Florence, Tabaglio, Tommaso, Zhang, JingXian, Wollmann, Heike, Chen, Leilei, An, Omer, Chan, Tim Hon Man, Hall Hickman, Alexander, Zheng, Simin, Roudko, Vladimir, Chen, Sujun, Karz, Alcida, Ahmed, Musaddeque, He, Housheng Hansen, Greenbaum, Benjamin D, Oliviero, Salvatore, Serresi, Michela, Gargiulo, Gaetano, Mann, Karen M, Hernando, Eva, Mulholland, David, Marazzi, Ivan, Wee, Dave Keng Boon, Guccione, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346284/
https://www.ncbi.nlm.nih.gov/pubmed/34075878
http://dx.doi.org/10.7554/eLife.59654

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