An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates

The SARS-CoV-2 pandemic has affected more than 185 million people worldwide resulting in over 4 million deaths. To contain the pandemic, there is a continued need for safe vaccines that provide durable protection at low and scalable doses and can be deployed easily. Here, AAVCOVID-1, an adeno-associ...

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Detalles Bibliográficos
Autores principales: Zabaleta, Nerea, Dai, Wenlong, Bhatt, Urja, Hérate, Cécile, Maisonnasse, Pauline, Chichester, Jessica A., Sanmiguel, Julio, Estelien, Reynette, Michalson, Kristofer T., Diop, Cheikh, Maciorowski, Dawid, Dereuddre-Bosquet, Nathalie, Cavarelli, Mariangela, Gallouët, Anne-Sophie, Naninck, Thibaut, Kahlaoui, Nidhal, Lemaitre, Julien, Qi, Wenbin, Hudspeth, Elissa, Cucalon, Allison, Dyer, Cecilia D., Pampena, M. Betina, Knox, James J., LaRocque, Regina C., Charles, Richelle C., Li, Dan, Kim, Maya, Sheridan, Abigail, Storm, Nadia, Johnson, Rebecca I., Feldman, Jared, Hauser, Blake M., Contreras, Vanessa, Marlin, Romain, Tsong Fang, Raphaël Ho, Chapon, Catherine, van der Werf, Sylvie, Zinn, Eric, Ryan, Aisling, Kobayashi, Dione T., Chauhan, Ruchi, McGlynn, Marion, Ryan, Edward T., Schmidt, Aaron G., Price, Brian, Honko, Anna, Griffiths, Anthony, Yaghmour, Sam, Hodge, Robert, Betts, Michael R., Freeman, Mason W., Wilson, James M., Le Grand, Roger, Vandenberghe, Luk H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346325/
https://www.ncbi.nlm.nih.gov/pubmed/34428428
http://dx.doi.org/10.1016/j.chom.2021.08.002

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