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The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers

BACKGROUND: Most studies showing association between mothers with obesity in pregnancy or excessive gestational weight gain (GWG) and adverse neonatal outcome were cross‐sectional or retrospective. Many included patients are with gestational diabetes mellitus (GDM), which is a strong risk factor for...

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Autores principales: Loh, Huai Heng, Taipin, Haslinda, Said, Asri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346371/
https://www.ncbi.nlm.nih.gov/pubmed/34401200
http://dx.doi.org/10.1002/osp4.512
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author Loh, Huai Heng
Taipin, Haslinda
Said, Asri
author_facet Loh, Huai Heng
Taipin, Haslinda
Said, Asri
author_sort Loh, Huai Heng
collection PubMed
description BACKGROUND: Most studies showing association between mothers with obesity in pregnancy or excessive gestational weight gain (GWG) and adverse neonatal outcome were cross‐sectional or retrospective. Many included patients are with gestational diabetes mellitus (GDM), which is a strong risk factor for this adverse outcome. There are no prospective studies on this topic in Malaysia. This study aimed to examine prospectively the effects of obesity in pregnancy and GWG, independent of GDM, on neonatal outcome. METHODS: Pregnant mothers in the first trimester, who presented to health clinics in Kuching, were screened. Mothers with existing diabetes mellitus or GDM were excluded using 75‐g oral glucose tolerance test during the first and second trimesters. Participants with the first trimester BMI ≥ 23 kg/m(2) were recruited as overweight/obese group, whereas those with BMI 18.5–22.9 kg/m(2) were taken as the comparison group. At every trimester visit, mothers' weights were recorded. Babies' birth weight and occurrence of adverse neonatal outcome were documented. RESULTS: There were 123 mothers recruited as overweight/obese group (mean BMI 29.0 kg/m(2 )± 4.45) and 102 mothers as comparison group (mean BMI 20.4 kg/m(2 )± 1.48). The number of low birth weight was similar between groups: 9.8% in overweight/obese group, 6.9% in the comparison group (p = 0.416). More than half of these babies were born to mothers with inadequate GWG (58.3% in obese group vs. 57.1% in control group, p = 0.077). There was no significant difference in the mean birth weight (3000 g ± 454.5 vs. 3038 g ± 340.8, p = 0.471), preterm delivery (8.13% vs. 3.92%, p = 0.193), and admission rate to neonatal intensive care unit (8.13% vs. 7.85%, p = 0.937) between groups. There was a positive correlation between the total GWG in overweight/obese group on baby's weight (r = 0.222, p = 0.013). Inadequate GWG was not correlated with lower birth weight (p = 0.052). CONCLUSIONS: Obesity in pregnancy was not associated with poor neonatal outcome in this small sample of women in Malaysia. Total GWG showed a weak correlation with baby's birth weight in overweight/obese group.
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spelling pubmed-83463712021-08-15 The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers Loh, Huai Heng Taipin, Haslinda Said, Asri Obes Sci Pract Original Articles BACKGROUND: Most studies showing association between mothers with obesity in pregnancy or excessive gestational weight gain (GWG) and adverse neonatal outcome were cross‐sectional or retrospective. Many included patients are with gestational diabetes mellitus (GDM), which is a strong risk factor for this adverse outcome. There are no prospective studies on this topic in Malaysia. This study aimed to examine prospectively the effects of obesity in pregnancy and GWG, independent of GDM, on neonatal outcome. METHODS: Pregnant mothers in the first trimester, who presented to health clinics in Kuching, were screened. Mothers with existing diabetes mellitus or GDM were excluded using 75‐g oral glucose tolerance test during the first and second trimesters. Participants with the first trimester BMI ≥ 23 kg/m(2) were recruited as overweight/obese group, whereas those with BMI 18.5–22.9 kg/m(2) were taken as the comparison group. At every trimester visit, mothers' weights were recorded. Babies' birth weight and occurrence of adverse neonatal outcome were documented. RESULTS: There were 123 mothers recruited as overweight/obese group (mean BMI 29.0 kg/m(2 )± 4.45) and 102 mothers as comparison group (mean BMI 20.4 kg/m(2 )± 1.48). The number of low birth weight was similar between groups: 9.8% in overweight/obese group, 6.9% in the comparison group (p = 0.416). More than half of these babies were born to mothers with inadequate GWG (58.3% in obese group vs. 57.1% in control group, p = 0.077). There was no significant difference in the mean birth weight (3000 g ± 454.5 vs. 3038 g ± 340.8, p = 0.471), preterm delivery (8.13% vs. 3.92%, p = 0.193), and admission rate to neonatal intensive care unit (8.13% vs. 7.85%, p = 0.937) between groups. There was a positive correlation between the total GWG in overweight/obese group on baby's weight (r = 0.222, p = 0.013). Inadequate GWG was not correlated with lower birth weight (p = 0.052). CONCLUSIONS: Obesity in pregnancy was not associated with poor neonatal outcome in this small sample of women in Malaysia. Total GWG showed a weak correlation with baby's birth weight in overweight/obese group. John Wiley and Sons Inc. 2021-04-09 /pmc/articles/PMC8346371/ /pubmed/34401200 http://dx.doi.org/10.1002/osp4.512 Text en © 2021 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Loh, Huai Heng
Taipin, Haslinda
Said, Asri
The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title_full The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title_fullStr The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title_full_unstemmed The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title_short The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title_sort effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346371/
https://www.ncbi.nlm.nih.gov/pubmed/34401200
http://dx.doi.org/10.1002/osp4.512
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