Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions

Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in individual human genetic backgrounds and thus for developing precision medicine. Here, we generate sensorimotor organoids containing physiologically functional neuromuscular junctions (NMJs) and apply the model to diff...

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Detalles Bibliográficos
Autores principales: Pereira, João D., DuBreuil, Daniel M., Devlin, Anna-Claire, Held, Aaron, Sapir, Yechiam, Berezovski, Eugene, Hawrot, James, Dorfman, Katherine, Chander, Vignesh, Wainger, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346474/
https://www.ncbi.nlm.nih.gov/pubmed/34362895
http://dx.doi.org/10.1038/s41467-021-24776-4

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