The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges

Biological and non-biological variables unrelated to acute myeloid leukemia (AML) preclude standard therapy in many settings, with “real world” patients under-represented in clinical trials and prognostic models. Here, using a case-based format, we illustrate the impact that socioeconomic and anthro...

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Autores principales: John, M. Joseph, Kuriakose, Philip, Smith, Mark, Roman, Eve, Tauro, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346514/
https://www.ncbi.nlm.nih.gov/pubmed/34362874
http://dx.doi.org/10.1038/s41408-021-00533-0
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author John, M. Joseph
Kuriakose, Philip
Smith, Mark
Roman, Eve
Tauro, Sudhir
author_facet John, M. Joseph
Kuriakose, Philip
Smith, Mark
Roman, Eve
Tauro, Sudhir
author_sort John, M. Joseph
collection PubMed
description Biological and non-biological variables unrelated to acute myeloid leukemia (AML) preclude standard therapy in many settings, with “real world” patients under-represented in clinical trials and prognostic models. Here, using a case-based format, we illustrate the impact that socioeconomic and anthropogeographical constraints can have on optimally managing AML in 4 different healthcare systems. The granular details provided, emphasize the need for the development and targeting of socioeconomic interventions that are commensurate with the changing landscape of AML therapeutics, in order to avoid worsening the disparity in outcomes between patients with biologically similar disease.
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spelling pubmed-83465142021-08-20 The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges John, M. Joseph Kuriakose, Philip Smith, Mark Roman, Eve Tauro, Sudhir Blood Cancer J Review Article Biological and non-biological variables unrelated to acute myeloid leukemia (AML) preclude standard therapy in many settings, with “real world” patients under-represented in clinical trials and prognostic models. Here, using a case-based format, we illustrate the impact that socioeconomic and anthropogeographical constraints can have on optimally managing AML in 4 different healthcare systems. The granular details provided, emphasize the need for the development and targeting of socioeconomic interventions that are commensurate with the changing landscape of AML therapeutics, in order to avoid worsening the disparity in outcomes between patients with biologically similar disease. Nature Publishing Group UK 2021-08-06 /pmc/articles/PMC8346514/ /pubmed/34362874 http://dx.doi.org/10.1038/s41408-021-00533-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
John, M. Joseph
Kuriakose, Philip
Smith, Mark
Roman, Eve
Tauro, Sudhir
The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges
title The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges
title_full The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges
title_fullStr The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges
title_full_unstemmed The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges
title_short The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges
title_sort long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346514/
https://www.ncbi.nlm.nih.gov/pubmed/34362874
http://dx.doi.org/10.1038/s41408-021-00533-0
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