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Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+)-mobilizing second messenger which uniquely mobilizes Ca(2+) from acidic endolysosomal organelles. However, the molecular identity of the NAADP receptor remains unknown. Given the necessity of the endolysosomal two-pore channel...

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Detalles Bibliográficos
Autores principales:	Zhang, Jiyuan, Guan, Xin, Shah, Kunal, Yan, Jiusheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346516/ https://www.ncbi.nlm.nih.gov/pubmed/34362892 http://dx.doi.org/10.1038/s41467-021-24735-z

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