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Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation

Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of Collagen Fiber Orientation Disorder in Tumor-associated Stroma (CFOD-TS) on Hematoxylin & Eosin (H&E) slide images were prognostic of Disease F...

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Autores principales: Li, Haojia, Bera, Kaustav, Toro, Paula, Fu, PingFu, Zhang, Zelin, Lu, Cheng, Feldman, Michael, Ganesan, Shridar, Goldstein, Lori J., Davidson, Nancy E., Glasgow, Akisha, Harbhajanka, Aparna, Gilmore, Hannah, Madabhushi, Anant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346522/
https://www.ncbi.nlm.nih.gov/pubmed/34362928
http://dx.doi.org/10.1038/s41523-021-00310-z
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author Li, Haojia
Bera, Kaustav
Toro, Paula
Fu, PingFu
Zhang, Zelin
Lu, Cheng
Feldman, Michael
Ganesan, Shridar
Goldstein, Lori J.
Davidson, Nancy E.
Glasgow, Akisha
Harbhajanka, Aparna
Gilmore, Hannah
Madabhushi, Anant
author_facet Li, Haojia
Bera, Kaustav
Toro, Paula
Fu, PingFu
Zhang, Zelin
Lu, Cheng
Feldman, Michael
Ganesan, Shridar
Goldstein, Lori J.
Davidson, Nancy E.
Glasgow, Akisha
Harbhajanka, Aparna
Gilmore, Hannah
Madabhushi, Anant
author_sort Li, Haojia
collection PubMed
description Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of Collagen Fiber Orientation Disorder in Tumor-associated Stroma (CFOD-TS) on Hematoxylin & Eosin (H&E) slide images were prognostic of Disease Free Survival (DFS) in early stage Estrogen Receptor Positive (ER+) Invasive Breast Cancers (IBC). A Cox regression model named M(CFOD-TS), was constructed using cohort S(t) (N = 78) to predict DFS based on CFOD-TS features. The prognostic performance of M(CFOD-TS) was validated on cohort S(v) (N = 219), a prospective clinical trial dataset (ECOG 2197). M(CFOD-TS) was prognostic of DFS in both S(t) and S(v), independent of clinicopathological variables. Additionally, the molecular pathways regarding cell cycle regulation were identified as being significantly associated with M(CFOD-TS) derived risk scores. Our results also found that collagen fiber organization was more ordered in patients with short DFS. Our study provided a H&E image-based pipeline to derive a potential prognostic biomarker for early stage ER+ IBC without the need of special collagen staining or advanced microscopy techniques.
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spelling pubmed-83465222021-08-20 Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation Li, Haojia Bera, Kaustav Toro, Paula Fu, PingFu Zhang, Zelin Lu, Cheng Feldman, Michael Ganesan, Shridar Goldstein, Lori J. Davidson, Nancy E. Glasgow, Akisha Harbhajanka, Aparna Gilmore, Hannah Madabhushi, Anant NPJ Breast Cancer Article Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of Collagen Fiber Orientation Disorder in Tumor-associated Stroma (CFOD-TS) on Hematoxylin & Eosin (H&E) slide images were prognostic of Disease Free Survival (DFS) in early stage Estrogen Receptor Positive (ER+) Invasive Breast Cancers (IBC). A Cox regression model named M(CFOD-TS), was constructed using cohort S(t) (N = 78) to predict DFS based on CFOD-TS features. The prognostic performance of M(CFOD-TS) was validated on cohort S(v) (N = 219), a prospective clinical trial dataset (ECOG 2197). M(CFOD-TS) was prognostic of DFS in both S(t) and S(v), independent of clinicopathological variables. Additionally, the molecular pathways regarding cell cycle regulation were identified as being significantly associated with M(CFOD-TS) derived risk scores. Our results also found that collagen fiber organization was more ordered in patients with short DFS. Our study provided a H&E image-based pipeline to derive a potential prognostic biomarker for early stage ER+ IBC without the need of special collagen staining or advanced microscopy techniques. Nature Publishing Group UK 2021-08-06 /pmc/articles/PMC8346522/ /pubmed/34362928 http://dx.doi.org/10.1038/s41523-021-00310-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Haojia
Bera, Kaustav
Toro, Paula
Fu, PingFu
Zhang, Zelin
Lu, Cheng
Feldman, Michael
Ganesan, Shridar
Goldstein, Lori J.
Davidson, Nancy E.
Glasgow, Akisha
Harbhajanka, Aparna
Gilmore, Hannah
Madabhushi, Anant
Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title_full Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title_fullStr Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title_full_unstemmed Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title_short Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title_sort collagen fiber orientation disorder from h&e images is prognostic for early stage breast cancer: clinical trial validation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346522/
https://www.ncbi.nlm.nih.gov/pubmed/34362928
http://dx.doi.org/10.1038/s41523-021-00310-z
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