Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction

The cysteine protease, caspase-8, undergoes dimerization, processing, and activation following stimulation of cells with death ligands such as TRAIL, and mediates TRAIL induction of the extrinsic apoptosis pathway. In addition, caspase-8 mediates TRAIL-induced activation of NF-κB and upregulation of...

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Detalles Bibliográficos
Autores principales: Cui, Zhibin, Dabas, Hadas, Leonard, Brandon C., Shiah, Jamie V., Grandis, Jennifer R., Johnson, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346537/
https://www.ncbi.nlm.nih.gov/pubmed/34362880
http://dx.doi.org/10.1038/s41419-021-04066-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346537/
https://www.ncbi.nlm.nih.gov/pubmed/34362880
http://dx.doi.org/10.1038/s41419-021-04066-z

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