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Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes

Budding yeast Dpb4 (POLE3/CHRAC17 in mammals) is a highly conserved histone fold protein that is shared by two protein complexes: the chromatin remodeler ISW2/hCHRAC and the DNA polymerase ε (Pol ε) holoenzyme. In Saccharomyces cerevisiae, Dpb4 forms histone-like dimers with Dls1 in the ISW2 complex...

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Detalles Bibliográficos
Autores principales:	Casari, Erika, Gobbini, Elisa, Gnugnoli, Marco, Mangiagalli, Marco, Clerici, Michela, Longhese, Maria Pia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346560/ https://www.ncbi.nlm.nih.gov/pubmed/34362907 http://dx.doi.org/10.1038/s41467-021-25090-9

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