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Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia

The mechanisms driving clonal heterogeneity and evolution in relapsed pediatric acute lymphoblastic leukemia (ALL) are not fully understood. We performed whole genome sequencing of samples collected at diagnosis, relapse(s) and remission from 29 Nordic patients. Somatic point mutations and large-sca...

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Detalles Bibliográficos
Autores principales:	Sayyab, Shumaila, Lundmark, Anders, Larsson, Malin, Ringnér, Markus, Nystedt, Sara, Marincevic-Zuniga, Yanara, Tamm, Katja Pokrovskaja, Abrahamsson, Jonas, Fogelstrand, Linda, Heyman, Mats, Norén-Nyström, Ulrika, Lönnerholm, Gudmar, Harila-Saari, Arja, Berglund, Eva C., Nordlund, Jessica, Syvänen, Ann-Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346595/ https://www.ncbi.nlm.nih.gov/pubmed/34362951 http://dx.doi.org/10.1038/s41598-021-95109-0

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