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A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells

Chinese hamster ovary (CHO) cells are the leading mammalian cell host employed to produce complex secreted recombinant biotherapeutics such as monoclonal antibodies (mAbs). Metabolic selection marker technologies (e.g. glutamine synthetase (GS) or dihydrofolate reductase (DHFR)) are routinely employ...

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Detalles Bibliográficos
Autores principales:	Budge, James D., Roobol, Joanne, Singh, Gurdeep, Mozzanino, Théo, Knight, Tanya J., Povey, Jane, Dean, Andrew, Turner, Sarah J., Jaques, Colin M., Young, Robert J., Racher, Andrew J., Smales, C. Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346673/ https://www.ncbi.nlm.nih.gov/pubmed/34386349 http://dx.doi.org/10.1016/j.mec.2021.e00179

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