Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia

There are no validated biomarkers for schizophrenia (SCZ), a disorder linked to neural network dysfunction. We demonstrate that collapsin response mediator protein-2 (CRMP2), a master regulator of cytoskeleton and, hence, neural circuitry, may form the basis for a biomarker because its activity is u...

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Detalles Bibliográficos
Autores principales: Nomoto, Munetaka, Konopaske, Glenn T., Yamashita, Naoya, Aoki, Reina, Jitsuki-Takahashi, Aoi, Nakamura, Haruko, Makihara, Hiroko, Saito, Mari, Saigusa, Yusuke, Nakamura, Fumio, Watanabe, Keisuke, Baba, Toshihiko, Benes, Francine M., Tobe, Brian T. D., Pernia, Cameron D., Coyle, Joseph T., Sidman, Richard L., Hirayasu, Yoshio, Snyder, Evan Y., Goshima, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346854/
https://www.ncbi.nlm.nih.gov/pubmed/34330827
http://dx.doi.org/10.1073/pnas.2100032118

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