The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs

The p53 pathway is a universal tumor suppressor mechanism that limits tumor progression by triggering apoptosis or permanent cell cycle arrest, called senescence. In recent years, efforts to reactivate p53 function in cancer have proven to be a successful therapeutic strategy in murine models and ha...

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Detalles Bibliográficos
Autores principales: Tesfaye, Ephrath, Martinez-Terroba, Elena, Bendor, Jordan, Winkler, Lauren, Olivero, Christiane, Chen, Kevin, Feldser, David M., Zamudio, Jesse R., Dimitrova, Nadya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346867/
https://www.ncbi.nlm.nih.gov/pubmed/34326251
http://dx.doi.org/10.1073/pnas.2025539118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346867/
https://www.ncbi.nlm.nih.gov/pubmed/34326251
http://dx.doi.org/10.1073/pnas.2025539118

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