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Three-color single-molecule imaging reveals conformational dynamics of dynein undergoing motility

The motor protein dynein undergoes coordinated conformational changes of its domains during motility along microtubules. Previous single-molecule studies analyzed the motion of the AAA rings of the dynein homodimer, but not the distal microtubule-binding domains (MTBDs) that step along the track. He...

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Detalles Bibliográficos
Autores principales:	Niekamp, Stefan, Stuurman, Nico, Zhang, Nan, Vale, Ronald D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346880/ https://www.ncbi.nlm.nih.gov/pubmed/34326255 http://dx.doi.org/10.1073/pnas.2101391118

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