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A comparative metabologenomic approach reveals mechanistic insights into Streptomyces antibiotic crypticity
Streptomyces genomes harbor numerous, biosynthetic gene clusters (BGCs) encoding for drug-like compounds. While some of these BGCs readily yield expected products, many do not. Biosynthetic crypticity represents a significant hurdle to drug discovery, and the biological mechanisms that underpin it r...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346890/ https://www.ncbi.nlm.nih.gov/pubmed/34326261 http://dx.doi.org/10.1073/pnas.2103515118 |