Cargando…
An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity
The present review is aimed at analysing the current evidence concerning the potential modulation of obesity and/or diet in adipose tissue ACE2. Additionally, the potential implications of these effects on COVID-19 are also addressed. The results published show that diet and obesity are two factors...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347022/ https://www.ncbi.nlm.nih.gov/pubmed/34360741 http://dx.doi.org/10.3390/ijms22157975 |
_version_ | 1783734983560527872 |
---|---|
author | Gómez-Zorita, Saioa Milton-Laskibar, Iñaki García-Arellano, Laura González, Marcela Portillo, María P. |
author_facet | Gómez-Zorita, Saioa Milton-Laskibar, Iñaki García-Arellano, Laura González, Marcela Portillo, María P. |
author_sort | Gómez-Zorita, Saioa |
collection | PubMed |
description | The present review is aimed at analysing the current evidence concerning the potential modulation of obesity and/or diet in adipose tissue ACE2. Additionally, the potential implications of these effects on COVID-19 are also addressed. The results published show that diet and obesity are two factors that effectively influence the expression of Ace2 gene in adipose tissue. However, the shifts in this gene do not always occur in the same direction, nor with the same intensity. Additionally, there is no consensus regarding the implications of increased adipose tissue ACE2 expression in health. Thus, while in some studies a protective role is attributed to ACE2 overexpression, other studies suggest otherwise. Similarly, there is much debate regarding the role played by ACE2 in COVID-19 in terms of degree of infection and disease outcomes. The greater risk of infection that may hypothetically derive from enhanced ACE2 expression is not clear since the functionality of the enzyme seems to be as important as the abundance. Thus, the greater abundance of ACE2 in adipose tissue of obese subjects may be counterbalanced by its lower activation. In addition, a protective role of ACE2 overexpression has also been suggested, associated with the increase in anti-inflammatory factors that it may produce. |
format | Online Article Text |
id | pubmed-8347022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83470222021-08-08 An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity Gómez-Zorita, Saioa Milton-Laskibar, Iñaki García-Arellano, Laura González, Marcela Portillo, María P. Int J Mol Sci Review The present review is aimed at analysing the current evidence concerning the potential modulation of obesity and/or diet in adipose tissue ACE2. Additionally, the potential implications of these effects on COVID-19 are also addressed. The results published show that diet and obesity are two factors that effectively influence the expression of Ace2 gene in adipose tissue. However, the shifts in this gene do not always occur in the same direction, nor with the same intensity. Additionally, there is no consensus regarding the implications of increased adipose tissue ACE2 expression in health. Thus, while in some studies a protective role is attributed to ACE2 overexpression, other studies suggest otherwise. Similarly, there is much debate regarding the role played by ACE2 in COVID-19 in terms of degree of infection and disease outcomes. The greater risk of infection that may hypothetically derive from enhanced ACE2 expression is not clear since the functionality of the enzyme seems to be as important as the abundance. Thus, the greater abundance of ACE2 in adipose tissue of obese subjects may be counterbalanced by its lower activation. In addition, a protective role of ACE2 overexpression has also been suggested, associated with the increase in anti-inflammatory factors that it may produce. MDPI 2021-07-26 /pmc/articles/PMC8347022/ /pubmed/34360741 http://dx.doi.org/10.3390/ijms22157975 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gómez-Zorita, Saioa Milton-Laskibar, Iñaki García-Arellano, Laura González, Marcela Portillo, María P. An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity |
title | An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity |
title_full | An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity |
title_fullStr | An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity |
title_full_unstemmed | An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity |
title_short | An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity |
title_sort | overview of adipose tissue ace2 modulation by diet and obesity. potential implications in covid-19 infection and severity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347022/ https://www.ncbi.nlm.nih.gov/pubmed/34360741 http://dx.doi.org/10.3390/ijms22157975 |
work_keys_str_mv | AT gomezzoritasaioa anoverviewofadiposetissueace2modulationbydietandobesitypotentialimplicationsincovid19infectionandseverity AT miltonlaskibarinaki anoverviewofadiposetissueace2modulationbydietandobesitypotentialimplicationsincovid19infectionandseverity AT garciaarellanolaura anoverviewofadiposetissueace2modulationbydietandobesitypotentialimplicationsincovid19infectionandseverity AT gonzalezmarcela anoverviewofadiposetissueace2modulationbydietandobesitypotentialimplicationsincovid19infectionandseverity AT portillomariap anoverviewofadiposetissueace2modulationbydietandobesitypotentialimplicationsincovid19infectionandseverity AT gomezzoritasaioa overviewofadiposetissueace2modulationbydietandobesitypotentialimplicationsincovid19infectionandseverity AT miltonlaskibarinaki overviewofadiposetissueace2modulationbydietandobesitypotentialimplicationsincovid19infectionandseverity AT garciaarellanolaura overviewofadiposetissueace2modulationbydietandobesitypotentialimplicationsincovid19infectionandseverity AT gonzalezmarcela overviewofadiposetissueace2modulationbydietandobesitypotentialimplicationsincovid19infectionandseverity AT portillomariap overviewofadiposetissueace2modulationbydietandobesitypotentialimplicationsincovid19infectionandseverity |