Computational Investigation of the pH Dependence of Stability of Melanosome Proteins: Implication for Melanosome formation and Disease

Intravesicular pH plays a crucial role in melanosome maturation and function. Melanosomal pH changes during maturation from very acidic in the early stages to neutral in late stages. Neutral pH is critical for providing optimal conditions for the rate-limiting, pH-sensitive melanin-synthesizing enzy...

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Detalles Bibliográficos
Autores principales: Koirala, Mahesh, Shashikala, H. B. Mihiri, Jeffries, Jacob, Wu, Bohua, Loftus, Stacie K., Zippin, Jonathan H., Alexov, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347052/
https://www.ncbi.nlm.nih.gov/pubmed/34361043
http://dx.doi.org/10.3390/ijms22158273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347052/
https://www.ncbi.nlm.nih.gov/pubmed/34361043
http://dx.doi.org/10.3390/ijms22158273

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