Osteoarthritis-Related Inflammation Blocks TGF-β’s Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region

Osteoarthritis (OA) is a degenerative joint disease characterized by irreversible cartilage damage, inflammation and altered chondrocyte phenotype. Transforming growth factor-β (TGF-β) signaling via SMAD2/3 is crucial for blocking hypertrophy. The post-translational modifications of these SMAD prote...

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Detalles Bibliográficos
Autores principales: Thielen, Nathalie, Neefjes, Margot, Wiegertjes, Renske, van den Akker, Guus, Vitters, Elly, van Beuningen, Henk, Blaney Davidson, Esmeralda, Koenders, Marije, van Lent, Peter, van de Loo, Fons, van Caam, Arjan, van der Kraan, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347103/
https://www.ncbi.nlm.nih.gov/pubmed/34360888
http://dx.doi.org/10.3390/ijms22158124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347103/
https://www.ncbi.nlm.nih.gov/pubmed/34360888
http://dx.doi.org/10.3390/ijms22158124

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