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Prognostic Significance of the Extranodal Extension of Regional Lymph Nodes in Stage III-N2 Non-Small-Cell Lung Cancer after Curative Resection

The present study investigated the prognostic role of extranodal extension (ENE) in stage III-N2 non-small-cell lung cancer (NSCLC) following curative surgery. From January 2005 to December 2018, pathologic stage III-N2 disease was diagnosed in 371 patients, all of whom underwent anatomic pulmonary...

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Autores principales: Shih, Beatrice Chia-Hui, Jeon, Jae Hyun, Chung, Jin-Haeng, Kwon, Hyun Jung, Lee, Jeong Hoon, Jung, Woohyun, Hwang, Yoohwa, Cho, Sukki, Kim, Kwhanmien, Jheon, Sanghoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347115/
https://www.ncbi.nlm.nih.gov/pubmed/34362108
http://dx.doi.org/10.3390/jcm10153324
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author Shih, Beatrice Chia-Hui
Jeon, Jae Hyun
Chung, Jin-Haeng
Kwon, Hyun Jung
Lee, Jeong Hoon
Jung, Woohyun
Hwang, Yoohwa
Cho, Sukki
Kim, Kwhanmien
Jheon, Sanghoon
author_facet Shih, Beatrice Chia-Hui
Jeon, Jae Hyun
Chung, Jin-Haeng
Kwon, Hyun Jung
Lee, Jeong Hoon
Jung, Woohyun
Hwang, Yoohwa
Cho, Sukki
Kim, Kwhanmien
Jheon, Sanghoon
author_sort Shih, Beatrice Chia-Hui
collection PubMed
description The present study investigated the prognostic role of extranodal extension (ENE) in stage III-N2 non-small-cell lung cancer (NSCLC) following curative surgery. From January 2005 to December 2018, pathologic stage III-N2 disease was diagnosed in 371 patients, all of whom underwent anatomic pulmonary resection accompanied by mediastinal lymph node dissection. This study included 282 patients, after excluding 89 patients who received preoperative chemotherapy or incomplete surgical resection. Their lymph nodes were processed; after hematoxylin and eosin staining, histopathologic slides of the metastatic nodes were reviewed by a designated pathologist. Predictors of disease free survival (DFS), including age, sex, operation type, pathologic T stage, nodal status, visceral pleural invasion, perioperative treatment, and the presence of ENE, were investigated. Among the 282 patients, ENE was detected in 85 patients (30.1%). ENE presence was associated with advanced T stage (p = 0.034), N2 subgroups (p < 0.001), lymphatic invasion (p = 0.001), and pneumonectomy (p = 0.002). The multivariable analysis demonstrated that old age (p < 0.001), advanced T stage (p = 0.012), N2 subgroups (p = 0.005), and ENE presence (p = 0.005) were significant independent predictors of DFS. The DFS rate at five years was 21.4% in patients who had ENE and 43.4% in patients who did not have ENE (p < 0.001). The presence of ENE, coupled with tumor-node-metastasis staging, should be recognized as a meaningful prognostic factor in stage III-N2 NSCLC patients.
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spelling pubmed-83471152021-08-08 Prognostic Significance of the Extranodal Extension of Regional Lymph Nodes in Stage III-N2 Non-Small-Cell Lung Cancer after Curative Resection Shih, Beatrice Chia-Hui Jeon, Jae Hyun Chung, Jin-Haeng Kwon, Hyun Jung Lee, Jeong Hoon Jung, Woohyun Hwang, Yoohwa Cho, Sukki Kim, Kwhanmien Jheon, Sanghoon J Clin Med Article The present study investigated the prognostic role of extranodal extension (ENE) in stage III-N2 non-small-cell lung cancer (NSCLC) following curative surgery. From January 2005 to December 2018, pathologic stage III-N2 disease was diagnosed in 371 patients, all of whom underwent anatomic pulmonary resection accompanied by mediastinal lymph node dissection. This study included 282 patients, after excluding 89 patients who received preoperative chemotherapy or incomplete surgical resection. Their lymph nodes were processed; after hematoxylin and eosin staining, histopathologic slides of the metastatic nodes were reviewed by a designated pathologist. Predictors of disease free survival (DFS), including age, sex, operation type, pathologic T stage, nodal status, visceral pleural invasion, perioperative treatment, and the presence of ENE, were investigated. Among the 282 patients, ENE was detected in 85 patients (30.1%). ENE presence was associated with advanced T stage (p = 0.034), N2 subgroups (p < 0.001), lymphatic invasion (p = 0.001), and pneumonectomy (p = 0.002). The multivariable analysis demonstrated that old age (p < 0.001), advanced T stage (p = 0.012), N2 subgroups (p = 0.005), and ENE presence (p = 0.005) were significant independent predictors of DFS. The DFS rate at five years was 21.4% in patients who had ENE and 43.4% in patients who did not have ENE (p < 0.001). The presence of ENE, coupled with tumor-node-metastasis staging, should be recognized as a meaningful prognostic factor in stage III-N2 NSCLC patients. MDPI 2021-07-28 /pmc/articles/PMC8347115/ /pubmed/34362108 http://dx.doi.org/10.3390/jcm10153324 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shih, Beatrice Chia-Hui
Jeon, Jae Hyun
Chung, Jin-Haeng
Kwon, Hyun Jung
Lee, Jeong Hoon
Jung, Woohyun
Hwang, Yoohwa
Cho, Sukki
Kim, Kwhanmien
Jheon, Sanghoon
Prognostic Significance of the Extranodal Extension of Regional Lymph Nodes in Stage III-N2 Non-Small-Cell Lung Cancer after Curative Resection
title Prognostic Significance of the Extranodal Extension of Regional Lymph Nodes in Stage III-N2 Non-Small-Cell Lung Cancer after Curative Resection
title_full Prognostic Significance of the Extranodal Extension of Regional Lymph Nodes in Stage III-N2 Non-Small-Cell Lung Cancer after Curative Resection
title_fullStr Prognostic Significance of the Extranodal Extension of Regional Lymph Nodes in Stage III-N2 Non-Small-Cell Lung Cancer after Curative Resection
title_full_unstemmed Prognostic Significance of the Extranodal Extension of Regional Lymph Nodes in Stage III-N2 Non-Small-Cell Lung Cancer after Curative Resection
title_short Prognostic Significance of the Extranodal Extension of Regional Lymph Nodes in Stage III-N2 Non-Small-Cell Lung Cancer after Curative Resection
title_sort prognostic significance of the extranodal extension of regional lymph nodes in stage iii-n2 non-small-cell lung cancer after curative resection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347115/
https://www.ncbi.nlm.nih.gov/pubmed/34362108
http://dx.doi.org/10.3390/jcm10153324
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