Preparation of Antiproliferative Terpene-Alkaloid Hybrids by Free Radical-Mediated Modification of ent-Kauranic Derivatives

A convenient strategy for molecular editing of available ent-kauranic natural scaffolds has been developed based on radical mediated C–C bond formation. Iodine atom transfer radical addition (ATRA) followed by rapid ionic elimination and radical azidoalkylation were investigated. Both reactions invo...

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Detalles Bibliográficos
Autores principales: Pruteanu, Elena, Gîrbu, Vladilena, Ungur, Nicon, Persoons, Leentje, Daelemans, Dirk, Renaud, Philippe, Kulcițki, Veaceslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347134/
https://www.ncbi.nlm.nih.gov/pubmed/34361708
http://dx.doi.org/10.3390/molecules26154549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347134/
https://www.ncbi.nlm.nih.gov/pubmed/34361708
http://dx.doi.org/10.3390/molecules26154549

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