The Highly Regioselective Synthesis of Novel Imidazolidin-2-Ones via the Intramolecular Cyclization/Electrophilic Substitution of Urea Derivatives and the Evaluation of Their Anticancer Activity

A series of novel 4-(het)arylimidazoldin-2-ones were obtained by the acid-catalyzed reaction of (2,2-diethoxyethyl)ureas with aromatic and heterocyclic C-nucleophiles. The proposed approach to substituted imidazolidinones benefits from excellent regioselectivity, readily available starting materials...

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Detalles Bibliográficos
Autores principales: Gazizov, Almir S., Smolobochkin, Andrey V., Kuznetsova, Elizaveta A., Abdullaeva, Dinara S., Burilov, Alexander R., Pudovik, Michail A., Voloshina, Alexandra D., Syakaev, Victor V., Lyubina, Anna P., Amerhanova, Syumbelya K., Voronina, Julia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347191/
https://www.ncbi.nlm.nih.gov/pubmed/34361587
http://dx.doi.org/10.3390/molecules26154432

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