Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer

Pancreatic cancer (PC), one of the most lethal solid tumors in humans, has a five-year survival rate of only 4%. Surgical treatment is the only accepted therapy with curative intent because the vast majority of these tumors are chemoresistant. Unfortunately, due to the aggressive nature of these tum...

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Autores principales: Nedelcu, Andreea, Mocan, Teodora, Grapa, Cristiana, Mocan, Lucian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347356/
https://www.ncbi.nlm.nih.gov/pubmed/34360829
http://dx.doi.org/10.3390/ijms22158060
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author Nedelcu, Andreea
Mocan, Teodora
Grapa, Cristiana
Mocan, Lucian
author_facet Nedelcu, Andreea
Mocan, Teodora
Grapa, Cristiana
Mocan, Lucian
author_sort Nedelcu, Andreea
collection PubMed
description Pancreatic cancer (PC), one of the most lethal solid tumors in humans, has a five-year survival rate of only 4%. Surgical treatment is the only accepted therapy with curative intent because the vast majority of these tumors are chemoresistant. Unfortunately, due to the aggressive nature of these tumors, fewer than 20% are resectable when the first symptoms occur. Novel therapies are required to overcome all these therapeutic issues, and the development of active nanocarriers represents an exciting opportunity to improve PC outcomes. The present review focuses on recent advances in the field of nanotechnology with application in PC treatment.
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spelling pubmed-83473562021-08-08 Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer Nedelcu, Andreea Mocan, Teodora Grapa, Cristiana Mocan, Lucian Int J Mol Sci Review Pancreatic cancer (PC), one of the most lethal solid tumors in humans, has a five-year survival rate of only 4%. Surgical treatment is the only accepted therapy with curative intent because the vast majority of these tumors are chemoresistant. Unfortunately, due to the aggressive nature of these tumors, fewer than 20% are resectable when the first symptoms occur. Novel therapies are required to overcome all these therapeutic issues, and the development of active nanocarriers represents an exciting opportunity to improve PC outcomes. The present review focuses on recent advances in the field of nanotechnology with application in PC treatment. MDPI 2021-07-28 /pmc/articles/PMC8347356/ /pubmed/34360829 http://dx.doi.org/10.3390/ijms22158060 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nedelcu, Andreea
Mocan, Teodora
Grapa, Cristiana
Mocan, Lucian
Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title_full Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title_fullStr Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title_full_unstemmed Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title_short Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title_sort recent advances in nanoparticle-mediated diagnosis and the treatment of pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347356/
https://www.ncbi.nlm.nih.gov/pubmed/34360829
http://dx.doi.org/10.3390/ijms22158060
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