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Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications

The current review aims to summarise the biodiversity and biosynthesis of novel secondary metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary metabolites produced that vary depending on its ecological environments they inhabit. Actinobacteria creates a wide range o...

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Autores principales: Al-shaibani, Muhanna Mohammed, Radin Mohamed, Radin Maya Saphira, Sidik, Nik Marzuki, Enshasy, Hesham Ali El, Al-Gheethi, Adel, Noman, Efaq, Al-Mekhlafi, Nabil Ali, Zin, Noraziah Mohamad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347454/
https://www.ncbi.nlm.nih.gov/pubmed/34361657
http://dx.doi.org/10.3390/molecules26154504
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author Al-shaibani, Muhanna Mohammed
Radin Mohamed, Radin Maya Saphira
Sidik, Nik Marzuki
Enshasy, Hesham Ali El
Al-Gheethi, Adel
Noman, Efaq
Al-Mekhlafi, Nabil Ali
Zin, Noraziah Mohamad
author_facet Al-shaibani, Muhanna Mohammed
Radin Mohamed, Radin Maya Saphira
Sidik, Nik Marzuki
Enshasy, Hesham Ali El
Al-Gheethi, Adel
Noman, Efaq
Al-Mekhlafi, Nabil Ali
Zin, Noraziah Mohamad
author_sort Al-shaibani, Muhanna Mohammed
collection PubMed
description The current review aims to summarise the biodiversity and biosynthesis of novel secondary metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary metabolites produced that vary depending on its ecological environments they inhabit. Actinobacteria creates a wide range of bioactive substances that can be of great value to public health and the pharmaceutical industry. The literature analysis process for this review was conducted using the VOSviewer software tool to visualise the bibliometric networks of the most relevant databases from the Scopus database in the period between 2010 and 22 March 2021. Screening and exploring the available literature relating to the extreme environments and ecosystems that Actinobacteria inhabit aims to identify new strains of this major microorganism class, producing unique novel bioactive compounds. The knowledge gained from these studies is intended to encourage scientists in the natural product discovery field to identify and characterise novel strains containing various bioactive gene clusters with potential clinical applications. It is evident that Actinobacteria adapted to survive in extreme environments represent an important source of a wide range of bioactive compounds. Actinobacteria have a large number of secondary metabolite biosynthetic gene clusters. They can synthesise thousands of subordinate metabolites with different biological actions such as anti-bacterial, anti-parasitic, anti-fungal, anti-virus, anti-cancer and growth-promoting compounds. These are highly significant economically due to their potential applications in the food, nutrition and health industries and thus support our communities’ well-being.
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spelling pubmed-83474542021-08-08 Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications Al-shaibani, Muhanna Mohammed Radin Mohamed, Radin Maya Saphira Sidik, Nik Marzuki Enshasy, Hesham Ali El Al-Gheethi, Adel Noman, Efaq Al-Mekhlafi, Nabil Ali Zin, Noraziah Mohamad Molecules Review The current review aims to summarise the biodiversity and biosynthesis of novel secondary metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary metabolites produced that vary depending on its ecological environments they inhabit. Actinobacteria creates a wide range of bioactive substances that can be of great value to public health and the pharmaceutical industry. The literature analysis process for this review was conducted using the VOSviewer software tool to visualise the bibliometric networks of the most relevant databases from the Scopus database in the period between 2010 and 22 March 2021. Screening and exploring the available literature relating to the extreme environments and ecosystems that Actinobacteria inhabit aims to identify new strains of this major microorganism class, producing unique novel bioactive compounds. The knowledge gained from these studies is intended to encourage scientists in the natural product discovery field to identify and characterise novel strains containing various bioactive gene clusters with potential clinical applications. It is evident that Actinobacteria adapted to survive in extreme environments represent an important source of a wide range of bioactive compounds. Actinobacteria have a large number of secondary metabolite biosynthetic gene clusters. They can synthesise thousands of subordinate metabolites with different biological actions such as anti-bacterial, anti-parasitic, anti-fungal, anti-virus, anti-cancer and growth-promoting compounds. These are highly significant economically due to their potential applications in the food, nutrition and health industries and thus support our communities’ well-being. MDPI 2021-07-26 /pmc/articles/PMC8347454/ /pubmed/34361657 http://dx.doi.org/10.3390/molecules26154504 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Al-shaibani, Muhanna Mohammed
Radin Mohamed, Radin Maya Saphira
Sidik, Nik Marzuki
Enshasy, Hesham Ali El
Al-Gheethi, Adel
Noman, Efaq
Al-Mekhlafi, Nabil Ali
Zin, Noraziah Mohamad
Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications
title Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications
title_full Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications
title_fullStr Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications
title_full_unstemmed Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications
title_short Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications
title_sort biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347454/
https://www.ncbi.nlm.nih.gov/pubmed/34361657
http://dx.doi.org/10.3390/molecules26154504
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