Cargando…

The Therapeutic Potential of Celastrol in Central Nervous System Disorders: Highlights from In Vitro and In Vivo Approaches

Celastrol, the most abundant compound derived from the root of Tripterygium wilfordii, largely used in traditional Chinese medicine, has shown preclinical and clinical efficacy for a broad range of disorders, acting via numerous mechanisms, including the induction of the expression of several neurop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schiavone, Stefania, Morgese, Maria Grazia, Tucci, Paolo, Trabace, Luigia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347599/ https://www.ncbi.nlm.nih.gov/pubmed/34361850 http://dx.doi.org/10.3390/molecules26154700

Ejemplares similares

Early Celastrol Administration Prevents Ketamine-Induced Psychotic-Like Behavioral Dysfunctions, Oxidative Stress and IL-10 Reduction in The Cerebellum of Adult Mice
por: Schiavone, Stefania, et al.
Publicado: (2019)

Postnatal Antioxidant and Anti-inflammatory Treatments Prevent Early Ketamine-Induced Cortical Dysfunctions in Adult Mice
por: Bove, Maria, et al.
Publicado: (2020)

Carvacrol: From Ancient Flavoring to Neuromodulatory Agent
por: Zotti, Margherita, et al.
Publicado: (2013)

Lifelong Nutritional Omega-3 Deficiency Evokes Depressive-Like State Through Soluble Beta Amyloid
por: Morgese, Maria Grazia, et al.
Publicado: (2016)

N-3 PUFA Prevent Oxidative Stress in a Rat Model of Beta-Amyloid-Induced Toxicity
por: Morgese, Maria Grazia, et al.
Publicado: (2021)

Effects of anabolic-androgens on brain reward function
por: Mhillaj, Emanuela, et al.
Publicado: (2015)

Chlorella sorokiniana Extract Improves Short-Term Memory in Rats
por: Morgese, Maria Grazia, et al.
Publicado: (2016)

Small Molecules: Therapeutic Application in Neuropsychiatric and Neurodegenerative Disorders
por: Schiavone, Stefania, et al.
Publicado: (2018)

Sublingual AKBA Exerts Antidepressant Effects in the Aβ-Treated Mouse Model
por: Morgese, Maria Grazia, et al.
Publicado: (2021)

Special Issue “Potential Neuromodulatory Profile of Phytocompounds in Brain Disorders”
por: Trabace, Luigia, et al.
Publicado: (2016)

Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour
por: Tucci, Paolo, et al.
Publicado: (2022)

Increased iNOS and Nitrosative Stress in Dopaminergic Neurons of MDMA-Exposed Rats
por: Schiavone, Stefania, et al.
Publicado: (2019)

Memantine prevents memory consolidation failure induced by soluble beta amyloid in rats
por: Tucci, Paolo, et al.
Publicado: (2014)

Maternal Malnutrition in the Etiopathogenesis of Psychiatric Diseases: Role of Polyunsaturated Fatty Acids
por: Morgese, Maria Grazia, et al.
Publicado: (2016)

Monoaminergic System Modulation in Depression and Alzheimer’s Disease: A New Standpoint?
por: Morgese, Maria Grazia, et al.
Publicado: (2019)

Precision Medicine in Alzheimer’s Disease: Investigating Comorbid Common Biological Substrates in the Rat Model of Amyloid Beta-Induced Toxicity
por: Morgese, Maria Grazia, et al.
Publicado: (2022)

Early Loss of Blood-Brain Barrier Integrity Precedes NOX2 Elevation in the Prefrontal Cortex of an Animal Model of Psychosis
por: Schiavone, Stefania, et al.
Publicado: (2016)

Inflammation, Stress Response, and Redox Dysregulation Biomarkers: Clinical Outcomes and Pharmacological Implications for Psychosis
por: Schiavone, Stefania, et al.
Publicado: (2017)

Chronic Psychosocial Stress Impairs Bone Homeostasis: A Study in the Social Isolation Reared Rat
por: Schiavone, Stefania, et al.
Publicado: (2016)

Visceral Fat Dysfunctions in the Rat Social Isolation Model of Psychosis
por: Schiavone, Stefania, et al.
Publicado: (2017)

Soluble beta amyloid evokes alteration in brain norepinephrine levels: role of nitric oxide and interleukin-1
por: Morgese, Maria G., et al.
Publicado: (2015)

The NADPH oxidase NOX2 mediates loss of parvalbumin interneurons in traumatic brain injury: human autoptic immunohistochemical evidence
por: Schiavone, Stefania, et al.
Publicado: (2017)

SARS-CoV-2 Gamma and Delta Variants of Concern Might Undermine Neutralizing Activity Generated in Response to BNT162b2 mRNA Vaccination
por: Trabace, Luigia, et al.
Publicado: (2022)

Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
por: Xu, Li-Na, et al.
Publicado: (2019)

The NADPH oxidase NOX2 as a novel biomarker for suicidality: evidence from human post mortem brain samples
por: Schiavone, S, et al.
Publicado: (2016)

Nanotechnology-Based Celastrol Formulations and Their Therapeutic Applications
por: Wagh, Pushkaraj Rajendra, et al.
Publicado: (2021)

The therapeutic potential of triptolide and celastrol in neurological diseases
por: Cui, Yueran, et al.
Publicado: (2022)

Novel Therapeutic Delivery of Nanocurcumin in Central Nervous System Related Disorders
por: Panzarini, Elisa, et al.
Publicado: (2020)

Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice
por: Lama, Adriano, et al.
Publicado: (2022)

Preparation of high drug-loading celastrol nanosuspensions and their anti-breast cancer activities in vitro and in vivo
por: Huang, Tiantian, et al.
Publicado: (2020)

Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach
por: Veerappan, Karpagam, et al.
Publicado: (2016)

Celastrol and Rhynchophylline in the mitigation of simulated muscle atrophy under in vitro
por: Wastag, Maksymilian, et al.
Publicado: (2022)

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
por: Wang, Huabo, et al.
Publicado: (2015)

Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol
por: Xiao-pei, Huang, et al.
Publicado: (2018)

Celastrol mitigates staphyloxanthin biosynthesis and biofilm formation in Staphylococcus aureus via targeting key regulators of virulence; in vitro and in vivo approach
por: Yehia, Fatma Al-zahraa A., et al.
Publicado: (2022)

Deoxyribozymes: New Therapeutics to Treat Central Nervous System Disorders
por: Grimpe, Barbara
Publicado: (2011)

Sex-tailored pharmacology and COVID-19: Next steps towards appropriateness and health equity()
por: Spini, Andrea, et al.
Publicado: (2021)

In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease
por: Booij, Tijmen H, et al.
Publicado: (2019)

Antibacterial Activity of an FtsZ Inhibitor Celastrol and Its Synergistic Effect with Vancomycin against Enterococci In Vitro and In Vivo
por: Lu, Xi, et al.
Publicado: (2023)

Correction: Systematic identification of celastrol-binding proteins reveals that Shoc2 is inhibited by celastrol
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_807g921k8qbq6pfj5upncpvscd