Cargando…

mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership

Cellular senescence is a form of proliferative arrest triggered in response to a wide variety of stimuli and characterized by unique changes in cell morphology and function. Although unable to divide, senescent cells remain metabolically active and acquire the ability to produce and secrete bioactiv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cayo, Angel, Segovia, Raúl, Venturini, Whitney, Moore-Carrasco, Rodrigo, Valenzuela, Claudio, Brown, Nelson
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347619/ https://www.ncbi.nlm.nih.gov/pubmed/34360912 http://dx.doi.org/10.3390/ijms22158149

Ejemplares similares

Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy
por: Cayo, Angel, et al.
Publicado: (2023)

Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro
por: Venturini, Whitney, et al.
Publicado: (2020)

Platelets, a Key Cell in Inflammation and Atherosclerosis Progression
por: Huilcaman, Ricardo, et al.
Publicado: (2022)

SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
por: Valenzuela, Claudio A., et al.
Publicado: (2019)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

mTOR‐autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine
por: Zhu, Mei‐Jia, et al.
Publicado: (2020)

Dissecting the role of mTOR complexes in cellular senescence
por: Serrano, Manuel
Publicado: (2012)

The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis
por: Valenzuela, Claudio A., et al.
Publicado: (2017)

The mTOR–Autophagy Axis and the Control of Metabolism
por: Deleyto-Seldas, Nerea, et al.
Publicado: (2021)

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition
por: Walters, Hannah E., et al.
Publicado: (2016)

mTORC2: The other mTOR in autophagy regulation
por: Ballesteros‐Álvarez, Josué, et al.
Publicado: (2021)

Autophagy termination and lysosome reformation regulated by mTOR
por: Yu, Li, et al.
Publicado: (2010)

mTOR's role in ageing: protein synthesis or autophagy?
por: Hands, Sarah L., et al.
Publicado: (2009)

mTOR, AMBRA1, and autophagy: An intricate relationship
por: Nazio, Francesca, et al.
Publicado: (2013)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis
por: Gui, Yao-Song, et al.
Publicado: (2015)

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease
por: Zhu, Zhou, et al.
Publicado: (2019)

Pleiotropic Effects of mTOR and Autophagy During Development and Aging
por: Schmeisser, Kathrin, et al.
Publicado: (2019)

The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases
por: Wang, Haojie, et al.
Publicado: (2019)

Celastrol promotes chondrocyte autophagy by regulating mTOR expression
por: Dai, Siming, et al.
Publicado: (2022)

Role of mTOR through Autophagy in Esophageal Cancer Stemness
por: Du, Liang, et al.
Publicado: (2022)

mTOR favors senescence over quiescence in p53-arrested cells
por: Schug, Thaddeus T.
Publicado: (2010)

mTOR signaling orchestrates the expression of cytoprotective factors during cellular senescence
por: Yosef, Reut, et al.
Publicado: (2016)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence
por: Strozyk, Elwira, et al.
Publicado: (2013)

High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression
por: Xue, Wen-Jiao, et al.
Publicado: (2022)

Curcumin Alleviates D-Galactose-Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway
por: Yang, Lei, et al.
Publicado: (2022)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

mTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling
por: Decuypere, Jean-Paul, et al.
Publicado: (2013)

Regulation of Autophagy in Chick Skeletal Muscle: Effect of mTOR Inhibition
por: Nakashima, Kazuki, et al.
Publicado: (2020)

Autophagy and mTOR signaling during intervertebral disc aging and degeneration
por: Yurube, Takashi, et al.
Publicado: (2020)

Hirudin inhibits glioma growth through mTOR‐regulated autophagy
por: Ma, Ying, et al.
Publicado: (2023)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor Senescence
por: Dillenburg, Caroline Siviero, et al.
Publicado: (2015)

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
por: Herranz, Nicolás, et al.
Publicado: (2015)

Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells
por: Antonioli, Eliane, et al.
Publicado: (2019)

Role of mTOR in the Development of Asthma in Mice With Cigarette Smoke-Induced Cellular Senescence
por: Lee, Hyun Seung, et al.
Publicado: (2021)

YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR
por: Pan, Xianmei, et al.
Publicado: (2020)

mTOR Inhibitor Rapalink-1 Prevents Ethanol-Induced Senescence in Endothelial Cells
por: Zhou, Huakang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bl2k6uit1tfu1dab80q7r03pod