A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging

Nitroreductase as a potential biomarker for aggressive tumors has received extensive attention. In this work, a novel NIR fluorescent probe for nitroreductase detection was synthesized. The probe Py-SiRh-NTR displayed excellent sensitivity and selectivity. Most importantly, the confocal fluorescence...

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Detalles Bibliográficos
Autores principales: Liu, Feng, Zhang, Hong, Li, Kun, Xie, Yongmei, Li, Zhihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347683/
https://www.ncbi.nlm.nih.gov/pubmed/34361578
http://dx.doi.org/10.3390/molecules26154425
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author Liu, Feng
Zhang, Hong
Li, Kun
Xie, Yongmei
Li, Zhihui
author_facet Liu, Feng
Zhang, Hong
Li, Kun
Xie, Yongmei
Li, Zhihui
author_sort Liu, Feng
collection PubMed
description Nitroreductase as a potential biomarker for aggressive tumors has received extensive attention. In this work, a novel NIR fluorescent probe for nitroreductase detection was synthesized. The probe Py-SiRh-NTR displayed excellent sensitivity and selectivity. Most importantly, the confocal fluorescence imaging demonstrated that HepG-2 cells treated with Py-SiRh-NTR under hypoxic conditions showed obvious enhanced fluorescence, which means that the NTR was overexpressed under hypoxic conditions. Moreover, the probe showed great promise that could help us to study related anticancer mechanisms research.
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spelling pubmed-83476832021-08-08 A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging Liu, Feng Zhang, Hong Li, Kun Xie, Yongmei Li, Zhihui Molecules Communication Nitroreductase as a potential biomarker for aggressive tumors has received extensive attention. In this work, a novel NIR fluorescent probe for nitroreductase detection was synthesized. The probe Py-SiRh-NTR displayed excellent sensitivity and selectivity. Most importantly, the confocal fluorescence imaging demonstrated that HepG-2 cells treated with Py-SiRh-NTR under hypoxic conditions showed obvious enhanced fluorescence, which means that the NTR was overexpressed under hypoxic conditions. Moreover, the probe showed great promise that could help us to study related anticancer mechanisms research. MDPI 2021-07-22 /pmc/articles/PMC8347683/ /pubmed/34361578 http://dx.doi.org/10.3390/molecules26154425 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Liu, Feng
Zhang, Hong
Li, Kun
Xie, Yongmei
Li, Zhihui
A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging
title A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging
title_full A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging
title_fullStr A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging
title_full_unstemmed A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging
title_short A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging
title_sort novel nir fluorescent probe for highly selective detection of nitroreductase and hypoxic-tumor-cell imaging
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347683/
https://www.ncbi.nlm.nih.gov/pubmed/34361578
http://dx.doi.org/10.3390/molecules26154425
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