Cargando…

Development of [(18)F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain

Cannabinoid receptors type 2 (CB2R) represent an attractive therapeutic target for neurodegenerative diseases and cancer. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor receptor density and/or occupancy during a CB2R-tailored therapy, we herein describe the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teodoro, Rodrigo, Gündel, Daniel, Deuther-Conrad, Winnie, Ueberham, Lea, Toussaint, Magali, Bormans, Guy, Brust, Peter, Moldovan, Rareş-Petru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347709/ https://www.ncbi.nlm.nih.gov/pubmed/34360817 http://dx.doi.org/10.3390/ijms22158051

Ejemplares similares

Synthesis, Structure–Activity Relationships, Radiofluorination, and Biological Evaluation of [(18)F]RM365, a Novel Radioligand for Imaging the Human Cannabinoid Receptor Type 2 (CB2R) in the Brain with PET
por: Teodoro, Rodrigo, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of a Novel (18)F-Labeled Radiotracer for PET Imaging of the Adenosine A(2A) Receptor
por: Lai, Thu Hang, et al.
Publicado: (2021)

Preclinical Evaluation of [(18)F]FACH in Healthy Mice and Piglets: An (18)F-Labeled Ligand for Imaging of Monocarboxylate Transporters with PET
por: Gündel, Daniel, et al.
Publicado: (2021)

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant (18)F-Labelled σ(2) Receptor Ligand
por: Moldovan, Rareş-Petru, et al.
Publicado: (2021)

Synthesis and Preliminary Biological Evaluation of Indol-3-yl-oxoacetamides as Potent Cannabinoid Receptor Type 2 Ligands
por: Moldovan, Rareş-Petru, et al.
Publicado: (2017)

Development of cannabinoid receptor (CB 2 R) ligands for application in PET studies - where to attach the radiolabel?
por: Günther, Robert, et al.
Publicado: (2014)

Preclinical Incorporation Dosimetry of [(18)F]FACH—A Novel (18)F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET
por: Sattler, Bernhard, et al.
Publicado: (2020)

Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB(2) receptors
por: Teodoro, Rodrigo, et al.
Publicado: (2013)

Development of a Radiofluorinated Adenosine A(2B) Receptor Antagonist as Potential Ligand for PET Imaging
por: Lindemann, Marcel, et al.
Publicado: (2020)

Improved in vivo PET imaging of the adenosine A(2A) receptor in the brain using [(18)F]FLUDA, a deuterated radiotracer with high metabolic stability
por: Lai, Thu Hang, et al.
Publicado: (2021)

Quantitation of the A(2A) Adenosine Receptor Density in the Striatum of Mice and Pigs with [(18)F]FLUDA by Positron Emission Tomography
por: Gündel, Daniel, et al.
Publicado: (2022)

Development of (18)F-Labeled Radiotracers for PET Imaging of the Adenosine A(2A) Receptor: Synthesis, Radiolabeling and Preliminary Biological Evaluation
por: Lai, Thu Hang, et al.
Publicado: (2021)

A 3D-QSAR model for cannabinoid receptor (CB2) ligands derived from aligned pharmacophors
por: Günther, Robert, et al.
Publicado: (2013)

PET Imaging of the Adenosine A(2A) Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [(18)F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy
por: Schröder, Susann, et al.
Publicado: (2020)

Development of Novel Analogs of the Monocarboxylate Transporter Ligand FACH and Biological Validation of One Potential Radiotracer for Positron Emission Tomography (PET) Imaging
por: Sadeghzadeh, Masoud, et al.
Publicado: (2020)

Non-Invasive Assessment of Locally Overexpressed Human Adenosine 2A Receptors in the Heart of Transgenic Mice
por: Gündel, Daniel, et al.
Publicado: (2022)

One-step radiosynthesis of the MCTs imaging agent [(18)F]FACH by aliphatic (18)F-labelling of a methylsulfonate precursor containing an unprotected carboxylic acid group
por: Sadeghzadeh, Masoud, et al.
Publicado: (2019)

Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [(18)F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain
por: Clauß, Oliver, et al.
Publicado: (2022)

Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine-Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography
por: Ritawidya, Rien, et al.
Publicado: (2019)

Radiosynthesis and Preclinical Evaluation of an (18)F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A)
por: Wenzel, Barbara, et al.
Publicado: (2022)

Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging
por: Moldovan, Rareş-Petru, et al.
Publicado: (2017)

Cannabinoid receptor type 2 (CB2)-selective N-aryl-oxadiazolyl-propionamides: synthesis, radiolabelling, molecular modelling and biological evaluation
por: Rühl, Thomas, et al.
Publicado: (2012)

Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using (S)-(−)-[(18)F]Fluspidine in Glioblastoma
por: Toussaint, Magali, et al.
Publicado: (2020)

Radiosynthesis and Radiotracer Properties of a 7-(2-[(18)F]Fluoroethoxy)-6-methoxypyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET
por: Funke, Uta, et al.
Publicado: (2012)

Exploring the Metabolism of (+)-[(18)F]Flubatine In Vitro and In Vivo: LC-MS/MS Aided Identification of Radiometabolites in a Clinical PET Study †
por: Ludwig, Friedrich-Alexander, et al.
Publicado: (2018)

Investigation of an (18)F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A
por: Schröder, Susann, et al.
Publicado: (2018)

Synthesis, (18)F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography
por: Schröder, Susann, et al.
Publicado: (2015)

Radiation dosimetry of the α(4)β(2) nicotinic receptor ligand (+)-[(18)F]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results
por: Kranz, Mathias, et al.
Publicado: (2016)

Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain
por: Liu, Jianrong, et al.
Publicado: (2016)

Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012
por: Schröder, Susann, et al.
Publicado: (2016)

Discovery and development of brain-penetrant (18)F-labeled radioligands for neuroimaging of the sigma-2 receptors
por: Zhang, Ying, et al.
Publicado: (2022)

Amphiphilic Anionic Oligomer-Stabilized Calcium Phosphate Nanoparticles with Prospects in siRNA Delivery via Convection-Enhanced Delivery
por: Mitrach, Franziska, et al.
Publicado: (2022)

In vitro and in vivo Human Metabolism of (S)-[(18)F]Fluspidine – A Radioligand for Imaging σ(1) Receptors With Positron Emission Tomography (PET)
por: Ludwig, Friedrich-Alexander, et al.
Publicado: (2019)

(18)F-MK-9470 PET imaging of the type 1 cannabinoid receptor in prostate carcinoma: a pilot study
por: Emonds, Kimy M, et al.
Publicado: (2013)

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A(2B) Receptor Binding Affinity
por: Lindemann, Marcel, et al.
Publicado: (2021)

A Promising PET Tracer for Imaging of α(7) Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand
por: Teodoro, Rodrigo, et al.
Publicado: (2015)

Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [(18)F]NS14490
por: Rötering, Sven, et al.
Publicado: (2014)

Radiofluorination of an Anionic, Azide-Functionalized Teroligomer by Copper-Catalyzed Azide-Alkyne Cycloaddition
por: Wenzel, Barbara, et al.
Publicado: (2023)

Bridging from Brain to Tumor Imaging: (S)-(−)- and (R)-(+)-[(18)F]Fluspidine for Investigation of Sigma-1 Receptors in Tumor-Bearing Mice †
por: Kranz, Mathias, et al.
Publicado: (2018)

(+)-[(18)F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand—results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls
por: Tiepolt, Solveig, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_uhkq8bc1tt30eqinphu3l7n0ur