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The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes
In recent decades, interest in natural compounds has increased exponentially due to their numerous beneficial properties in the treatment of various acute and chronic diseases. A group of plant derivatives with great scientific interest is terpenic compounds. Among the plants richest in terpenes, th...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347728/ https://www.ncbi.nlm.nih.gov/pubmed/34360675 http://dx.doi.org/10.3390/ijms22157910 |
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author | Maiuolo, Jessica Bava, Irene Carresi, Cristina Gliozzi, Micaela Musolino, Vincenzo Scicchitano, Miriam Macri, Roberta Oppedisano, Francesca Scarano, Federica Caterina Zito, Maria Bosco, Francesca Ruga, Stefano Nucera, Saverio Ilari, Sara Palma, Ernesto Muscoli, Carolina Mollace, Vincenzo |
author_facet | Maiuolo, Jessica Bava, Irene Carresi, Cristina Gliozzi, Micaela Musolino, Vincenzo Scicchitano, Miriam Macri, Roberta Oppedisano, Francesca Scarano, Federica Caterina Zito, Maria Bosco, Francesca Ruga, Stefano Nucera, Saverio Ilari, Sara Palma, Ernesto Muscoli, Carolina Mollace, Vincenzo |
author_sort | Maiuolo, Jessica |
collection | PubMed |
description | In recent decades, interest in natural compounds has increased exponentially due to their numerous beneficial properties in the treatment of various acute and chronic diseases. A group of plant derivatives with great scientific interest is terpenic compounds. Among the plants richest in terpenes, the genus Ferula L. is one of the most representative, and ferutinin, the most common sesquiterpene, is extracted from the leaves, rhizome, and roots of this plant. As reported in the scientific literature, ferutinin possesses antioxidant and anti-inflammatory properties, as well as valuable estrogenic properties. Neurodegenerative and demyelinating diseases are devastating conditions for which a definite cure has not yet been established. The mechanisms involved in these diseases are still poorly understood, and oxidative stress is considered to be both a key modulator and a common denominator. In the proposed experimental system, co-cultured human neurons (SH-SY5Y) and human oligodendrocytes (MO3.13) were treated with the pro-inflammatory agent lipopolysaccharide at a concentration of 1 μg/mL for 24 h or pretreated with ferutinin (33 nM) for 24 h and subsequently exposed to lipopolysaccharide 1 μg/mL for 24 h. Further studies would, however, be needed to establish whether this natural compound can be used as a support strategy in pathologies characterized by progressive inflammation and oxidative stress phenomena. |
format | Online Article Text |
id | pubmed-8347728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83477282021-08-08 The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes Maiuolo, Jessica Bava, Irene Carresi, Cristina Gliozzi, Micaela Musolino, Vincenzo Scicchitano, Miriam Macri, Roberta Oppedisano, Francesca Scarano, Federica Caterina Zito, Maria Bosco, Francesca Ruga, Stefano Nucera, Saverio Ilari, Sara Palma, Ernesto Muscoli, Carolina Mollace, Vincenzo Int J Mol Sci Article In recent decades, interest in natural compounds has increased exponentially due to their numerous beneficial properties in the treatment of various acute and chronic diseases. A group of plant derivatives with great scientific interest is terpenic compounds. Among the plants richest in terpenes, the genus Ferula L. is one of the most representative, and ferutinin, the most common sesquiterpene, is extracted from the leaves, rhizome, and roots of this plant. As reported in the scientific literature, ferutinin possesses antioxidant and anti-inflammatory properties, as well as valuable estrogenic properties. Neurodegenerative and demyelinating diseases are devastating conditions for which a definite cure has not yet been established. The mechanisms involved in these diseases are still poorly understood, and oxidative stress is considered to be both a key modulator and a common denominator. In the proposed experimental system, co-cultured human neurons (SH-SY5Y) and human oligodendrocytes (MO3.13) were treated with the pro-inflammatory agent lipopolysaccharide at a concentration of 1 μg/mL for 24 h or pretreated with ferutinin (33 nM) for 24 h and subsequently exposed to lipopolysaccharide 1 μg/mL for 24 h. Further studies would, however, be needed to establish whether this natural compound can be used as a support strategy in pathologies characterized by progressive inflammation and oxidative stress phenomena. MDPI 2021-07-24 /pmc/articles/PMC8347728/ /pubmed/34360675 http://dx.doi.org/10.3390/ijms22157910 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Maiuolo, Jessica Bava, Irene Carresi, Cristina Gliozzi, Micaela Musolino, Vincenzo Scicchitano, Miriam Macri, Roberta Oppedisano, Francesca Scarano, Federica Caterina Zito, Maria Bosco, Francesca Ruga, Stefano Nucera, Saverio Ilari, Sara Palma, Ernesto Muscoli, Carolina Mollace, Vincenzo The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes |
title | The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes |
title_full | The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes |
title_fullStr | The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes |
title_full_unstemmed | The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes |
title_short | The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes |
title_sort | effect of ferula communis extract in escherichia coli lipopolysaccharide-induced neuroinflammation in cultured neurons and oligodendrocytes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347728/ https://www.ncbi.nlm.nih.gov/pubmed/34360675 http://dx.doi.org/10.3390/ijms22157910 |
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