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Roscovitine, a Cyclin-Dependent Kinase-5 Inhibitor, Decreases Phosphorylated Tau Formation and Death of Retinal Ganglion Cells of Rats after Optic Nerve Crush

Tauopathies are neurodegenerative diseases characterized by abnormal metabolism of misfolded tau proteins and are progressive. Pathological phosphorylation of tau occurs in the retinal ganglion cells (RGCs) after optic nerve injuries. Cyclin-dependent kinase-5 (Cdk5) causes hyperphosphorylation of t...

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Detalles Bibliográficos
Autores principales:	Hirokawa, Takahisa, Horie, Taeko, Fukiyama, Yurie, Mimura, Masashi, Takai, Shinji, Kida, Teruyo, Oku, Hidehiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347789/ https://www.ncbi.nlm.nih.gov/pubmed/34360858 http://dx.doi.org/10.3390/ijms22158096

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