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Staphylococcus aureus Decreases SUMOylation Host Response to Promote Intramacrophage Survival
Staphylococcus aureus is a commensal bacterium that causes severe infections in soft tissue and the bloodstream. During infection, S. aureus manipulates host cell response to facilitate its own replication and dissemination. Here, we show that S. aureus significantly decreases the level of SUMOylati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347835/ https://www.ncbi.nlm.nih.gov/pubmed/34360873 http://dx.doi.org/10.3390/ijms22158108 |
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author | Youssouf, Nadhuma Recasens-Zorzo, Clara Molle, Virginie Bossis, Guillaume Soubeyran, Philippe Gannoun-Zaki, Laila |
author_facet | Youssouf, Nadhuma Recasens-Zorzo, Clara Molle, Virginie Bossis, Guillaume Soubeyran, Philippe Gannoun-Zaki, Laila |
author_sort | Youssouf, Nadhuma |
collection | PubMed |
description | Staphylococcus aureus is a commensal bacterium that causes severe infections in soft tissue and the bloodstream. During infection, S. aureus manipulates host cell response to facilitate its own replication and dissemination. Here, we show that S. aureus significantly decreases the level of SUMOylation, an essential post-translational modification, in infected macrophages 24 h post-phagocytosis. The reduced level of SUMOylation correlates with a decrease in the SUMO-conjugating enzyme Ubc9. The over-expression of SUMO proteins in macrophages impaired bacterial intracellular proliferation and the inhibition of SUMOylation with ML-792 increased it. Together, these findings demonstrated for the first time the role of host SUMOylation response toward S. aureus infection. |
format | Online Article Text |
id | pubmed-8347835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83478352021-08-08 Staphylococcus aureus Decreases SUMOylation Host Response to Promote Intramacrophage Survival Youssouf, Nadhuma Recasens-Zorzo, Clara Molle, Virginie Bossis, Guillaume Soubeyran, Philippe Gannoun-Zaki, Laila Int J Mol Sci Brief Report Staphylococcus aureus is a commensal bacterium that causes severe infections in soft tissue and the bloodstream. During infection, S. aureus manipulates host cell response to facilitate its own replication and dissemination. Here, we show that S. aureus significantly decreases the level of SUMOylation, an essential post-translational modification, in infected macrophages 24 h post-phagocytosis. The reduced level of SUMOylation correlates with a decrease in the SUMO-conjugating enzyme Ubc9. The over-expression of SUMO proteins in macrophages impaired bacterial intracellular proliferation and the inhibition of SUMOylation with ML-792 increased it. Together, these findings demonstrated for the first time the role of host SUMOylation response toward S. aureus infection. MDPI 2021-07-28 /pmc/articles/PMC8347835/ /pubmed/34360873 http://dx.doi.org/10.3390/ijms22158108 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Youssouf, Nadhuma Recasens-Zorzo, Clara Molle, Virginie Bossis, Guillaume Soubeyran, Philippe Gannoun-Zaki, Laila Staphylococcus aureus Decreases SUMOylation Host Response to Promote Intramacrophage Survival |
title | Staphylococcus aureus Decreases SUMOylation Host Response to Promote Intramacrophage Survival |
title_full | Staphylococcus aureus Decreases SUMOylation Host Response to Promote Intramacrophage Survival |
title_fullStr | Staphylococcus aureus Decreases SUMOylation Host Response to Promote Intramacrophage Survival |
title_full_unstemmed | Staphylococcus aureus Decreases SUMOylation Host Response to Promote Intramacrophage Survival |
title_short | Staphylococcus aureus Decreases SUMOylation Host Response to Promote Intramacrophage Survival |
title_sort | staphylococcus aureus decreases sumoylation host response to promote intramacrophage survival |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347835/ https://www.ncbi.nlm.nih.gov/pubmed/34360873 http://dx.doi.org/10.3390/ijms22158108 |
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